109887-52-7

Basic information

• Product Name: trans-3-Ethoxycarbonyl-4-(4-flurophenyl)-N-methyl piperdine-2,6-dione
• Synonyms: 3-PIPERIDINECARBOXYLIC ACID, 4-(4-FLUOROPHENYL)-1-METHYL-2,6-DIOXO-, ETHYL ESTER;(+/-)-TRANS-3-ETHOXYCARBONYL-4-(4-FLUOROPHENYL)-1-METHYLPIPERIDINE-2,6-DIONE;TRANS-3-ETHOXY CARBONYL-4-(4-FLUOROPHENYL)-N-METHYL PIPERIDIN-2,6-DIONE;(+/-)TRANS-3-ETHOXY CARBONYL-4-(4-FLUOROPHENYL)-N-METHYL PIPERIDINE-2,6-DIONE;TRANS-3-ETHOXYCARBONYL-4-(4-FLUOROPHENYL)-N-METHYL PIPERIDINE-2,6-DIONE;trans-3-ethoxycarbonyl-4-(4-flurophenyl)-n-methyl piperdine-2,6-dione;(+/-)Trans-3-ethoxy carbonyl-4-(4-flurophenyl)-N-methyl piperidine-2,6-dinone;Trans-3-ethoxycarbonyl-4-(4-fluorophenyl)-1-methylpiper-dine-2,6-dione
• CAS NO: 109887-52-7
• Molecular Formula: C15H16FNO4
• Molecular Weight: 293.29
• Product Categories: chiral
• Mol File: 109887-52-7.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 424.9 °C at 760 mmHg
• Flash Point: 210.7 °C
• Appearance: /
• Density: 1.258 g/cm³
• Vapor Pressure: 2E-07mmHg at 25°C
• Refractive Index: 1.526
• Storage Temp.: 2-8°C
• PKA: 8.69±0.40(Predicted)
• CAS DataBase Reference: trans-3-Ethoxycarbonyl-4-(4-flurophenyl)-N-methyl piperdine-2,6-dione(CAS DataBase Reference)
• NIST Chemistry Reference: trans-3-Ethoxycarbonyl-4-(4-flurophenyl)-N-methyl piperdine-2,6-dione(109887-52-7)
• EPA Substance Registry System: trans-3-Ethoxycarbonyl-4-(4-flurophenyl)-N-methyl piperdine-2,6-dione(109887-52-7)

Safety Data

• Hazardous Substances Data: 109887-52-7(Hazardous Substances Data)

Usage

General Description

"Trans-3-Ethoxycarbonyl-4-(4-flurophenyl)-N-methyl piperdine-2,6-dione" is a chemical compound that belongs to the piperidine class. It is a derivative of N-methyl piperdine-2,6-dione and is substituted with an ethoxycarbonyl group at the 3-position and a 4-(4-fluorophenyl) group at the 4-position. trans-3-Ethoxycarbonyl-4-(4-flurophenyl)-N-methyl piperdine-2,6-dione has potential pharmaceutical applications and may exhibit biological activity due to its structural characteristics. It can be synthesized through organic synthesis processes and may be used as a reference standard in analytical chemistry and pharmacology studies. Further research and testing may be required to fully understand the properties and potential applications of this compound.

InChI:InChI=1/C15H16FNO4/c1-3-21-15(20)13-11(8-12(18)17(2)14(13)19)9-4-6-10(16)7-5-9/h4-7,11,13H,3,8H2,1-2H3/t11-,13-/m1/s1

Upstream product

• 71510-95-7 2-carboethoxy-N-methyl-acetamide 
• 459-57-4 4-fluorobenzaldehyde 
• 391937-08-9 trans-3-ethoxycarbonyl-4(4'-fluorophenyl)piperidin-2,6-dione 
• 74-88-4 methyl iodide 
• 459-32-5 (E)-4-fluorocinnamic acid 
• 459-32-5 4-fluorocinnamic acid 
• 76311-95-0 methyl 3-(methylamino)-3-oxopropanoate 

Downstream Products

• 253768-88-6 (3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine-1-carboxylic acid phenyl ester 
• 110429-36-2 (3S,4R)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-1-methylpiperidine 

Relevant articles and documents

Improved process for paroxetine hydrochloride substantially free from potential impurities

An efficient process for production of paroxetine hydrochloride hemihydrate 1, a selective 5-hydroxytryptamine (serotonin) reuptake inhibitor, is described. Identification and control of potential impurities and establishment of efficient downstream workup procedures enabled us to produce paroxetine hydrochloride hemihydrate 1 efficiently.

Catalytic Michael/Ring-Closure Reaction of α,β-Unsaturated Pyrazoleamides with Amidomalonates: Asymmetric Synthesis of (?)-Paroxetine

A highly enantioselective tandem Michael/ring-closure reaction of α,β-unsaturated pyrazoleamides and amidomalonates has been accomplished in the presence of a chiral N,N′-dioxide–Yb(OTf)3complex (Tf: trifluoromethanesulfonyl) to give various substituted chiral glutarimides with high yields and diastereo- and enantioselectivities. Moreover, this methodology could be used for gram-scale manipulation and was successfully applied to the synthesis of (?)-paroxetine. Further nonlinear and HRMS studies revealed that the real catalytically active species was a monomeric L-PMe2–Yb3+complex. A plausible transition state was proposed to explain the origin of the asymmetric induction.

An efficient and stereoselective synthesis of (3S,4R)-(-)-trans-4- (4′-fluorophenyl)-3-hydroxymethyl-N-methylpiperidine

An asymmetric conjugate addition reaction between a chiral α,β-unsaturated amido ester and ethyl-N-methylmalonamide has been used as a key step in the synthesis of (3S,4R)-(-)-trans-4-(4′- fluorophenyl)-3-hydroxymethyl-N-methylpiperidine, a key intermediate for (-)-paroxetine.