109888-59-7

Basic information

• Product Name: 3-(4-CHLORO-PHENYL)-4,5-DIHYDRO-ISOXAZOLE-5-CARBOXYLIC ACID
• Synonyms: ASINEX-REAG BAS 09529458;3-(4-CHLORO-PHENYL)-4,5-DIHYDRO-ISOXAZOLE-5-CARBOXYLIC ACID
• CAS NO: 109888-59-7
• Molecular Formula: C₁₀H₈ClNO₃
• Molecular Weight: 225.63
• Mol File: 109888-59-7.mol
• Article Data: 2

Chemical Properties

• Melting Point: 168.5-169.5 °C
• Boiling Point: 389.5±52.0 °C(Predicted)
• Appearance: /
• Density: 1.48±0.1 g/cm3(Predicted)
• PKA: 2.73±0.40(Predicted)
• CAS DataBase Reference: 3-(4-CHLORO-PHENYL)-4,5-DIHYDRO-ISOXAZOLE-5-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-CHLORO-PHENYL)-4,5-DIHYDRO-ISOXAZOLE-5-CARBOXYLIC ACID(109888-59-7)
• EPA Substance Registry System: 3-(4-CHLORO-PHENYL)-4,5-DIHYDRO-ISOXAZOLE-5-CARBOXYLIC ACID(109888-59-7)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 109888-59-7(Hazardous Substances Data)

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 3717-24-6 4-chlorobenzaldehyde oxime 
• 79-10-7 acrylic acid 

Downstream Products

• 1174749-29-1 N-[3-(4-{4-(3-(4-chloro-phenyl)-4,5-dihydro-isoxazole-5-carbonyl)-piperazin-1-yl}-3-fluoro-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide 
• 1394002-26-6 C₁₈H₁₂Cl₂N₂O₃ 
• 1407515-90-5 C₁₇H₁₁ClN₂O₃ 

Relevant articles and documents

Anthranilic acid-based diamides derivatives incorporating aryl-isoxazoline pharmacophore as potential anticancer agents: Design, synthesis and biological evaluation

A series of novel anthranilic diamides derivatives containing aryl-isoxazoline moiety were designed and synthesized as a part of our ongoing search for potential anticancer agents. Their structures were confirmed by 1H NMR, 13C NMR and ESI-MS analyses. The preliminary assays showed that some of the compounds displayed moderate to good antitumor activities against human lung cancer (NCI-H460), hepatocellular liver carcinoma (HepG2), gastric cancer (SGC-7901 and BGC-823) and breast epithelial adenocarcinoma (MCF-7) cell lines at μM level, which might be developed as novel lead scaffold for potential anticancer agents.