109905-93-3Relevant academic research and scientific papers
Pure enantiomers of 4,5-disubstituted gamma-butyrolactams, and their use as antiamnestic agents
-
, (2008/06/13)
The invention provides pure enatiomers of 4,5-disubstituted γ-butyrolactams of the general formula STR1 By means of the pure enantiomers of 4,5-disubstituted γ-butyrolactams (I), according to the invention, it is now possible to synthesize (+)-(3R), (4S), (5S), (7R)-3-hydroxy-5-α-hydroxybenzyl-1-methyl-4-phenyl-pyrrolidin-2-one and derivatives in the form of pure enantiomers.
Diastereoselective and Enantioselective Total Synthesis of the Hepatoprotective Agent Clausenamide
Hartwig, Wolfgang,Born, Liborius
, p. 4352 - 4358 (2007/10/02)
The diastereoselective total synthesis of the naturally ocurring hepatoprotective agent clausenamide (3-hydroxy-5-(α-hydroxybenzyl)-1-methyl-4-phenylpyrrolidin-2-one) is described, starting from ethyl cinnamate and diethyl acetamidomalonate.The enantioselective total synthesis of optically pure (+)-clausenamide is presented.The synthesis is based on a novel method for the preparation of optically pure (2S,3S)-3-phenylglutamic acid.
