1099103-17-9Relevant academic research and scientific papers
COMPOUNDS FOR MODULATING DDAH AND ADMA LEVELS, AS WELL AS METHODS OF USING THEREOF TO TREAT DISEASE
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Page/Page column 106; 107, (2019/11/19)
Disclosed are compounds that can modulate DDAH and the amount of asymmetric dimethylarginine (ADMA) in a subject. Also provided are pharmaceutical compositions comprising these compounds, as well as methods of using these compositions to treat and/or prevent diseases associated with elevated or low levels of DDAH and ADMA.
Rhodium(III)-Catalyzed Synthesis of Spiropiperidine Derivatives via C-H Activation
Peneau, Augustin,Retailleau, Pascal,Guillou, Catherine,Chabaud, Laurent
, p. 2324 - 2340 (2018/02/23)
Spiropiperidine derivatives, an important class of bioactive molecules, were synthesized under mild conditions by rhodium(III)-catalyzed intramolecular ArC-H activation. This reaction provides a novel route to highly substituted tricyclic spiropiperidines in good to excellent yields. Under acidic conditions the resulting enamines reacted with pendant amides to afford spiropiperidines derivatives possessing an original tetracyclic structure.
