109912-28-9

Basic information

• Product Name: N-(4-Methoxybenzyl)-N-2-pyridinyl-1,2-ethanediamine
• Synonyms: N-[(4-Methoxyphenyl)Methyl]-N-2-pyridinyl-1,2-ethanediaMine
• CAS NO: 109912-28-9
• Molecular Formula: C₁₅H₁₉N₃O
• Molecular Weight: 257.33
• Product Categories: Aromatics Compounds;Aromatics;Intermediates
• Mol File: 109912-28-9.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• CAS DataBase Reference: N-(4-Methoxybenzyl)-N-2-pyridinyl-1,2-ethanediamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Methoxybenzyl)-N-2-pyridinyl-1,2-ethanediamine(109912-28-9)
• EPA Substance Registry System: N-(4-Methoxybenzyl)-N-2-pyridinyl-1,2-ethanediamine(109912-28-9)

Safety Data

• Hazardous Substances Data: 109912-28-9(Hazardous Substances Data)

Usage

Description

N-(4-Methoxybenzyl)-N-2-pyridinyl-1,2-ethanediamine, with the CAS number 109912-28-9, is a light yellow oil compound that is primarily utilized in the field of organic synthesis. Its unique chemical structure allows it to serve as a versatile building block for the creation of various complex organic molecules.

Uses

Used in Organic Synthesis:
N-(4-Methoxybenzyl)-N-2-pyridinyl-1,2-ethanediamine is used as a synthetic intermediate for the development of a wide range of organic compounds. Its application in this field is due to its ability to react with various functional groups, enabling the formation of diverse molecular structures.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, N-(4-Methoxybenzyl)-N-2-pyridinyl-1,2-ethanediamine is used as a key component in the synthesis of various drugs. Its presence in the molecular structure can contribute to the desired pharmacological properties, such as improved bioavailability, enhanced efficacy, or reduced side effects.
Used in Chemical Research:
N-(4-Methoxybenzyl)-N-2-pyridinyl-1,2-ethanediamine is also employed in chemical research as a model compound for studying various reaction mechanisms and exploring new synthetic routes. Its unique structure allows researchers to gain insights into the reactivity of different functional groups and develop innovative strategies for organic synthesis.

Upstream product

• 109-04-6 2-bromo-pyridine 
• 74764-17-3 2-[(pyridin-2-yl)amino]ethylamine 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 149841-54-3 N-cyano-N'-[2-[N-[2-[N-(4-methoxybenzyl)-N-(2-pyridyl)amino]ethyl]-N-methylamino]ethyl]-N''-[3-[3-(piperidinomethyl)phenoxy]propyl]guanidine 
• 149841-55-4 N-cyano-N'-[3-[N-[2-[N-(4-methoxybenzyl)-N-(2-pyridyl)amino]ethyl]-N-methylamino]propyl]-N''-[3-[3-(piperidinomethyl)phenoxy]propyl]guanidine 
• 149841-56-5 N-cyano-N'-[4-[N-[2-[N-(4-methoxybenzyl)-N-(2-pyridyl)amino]ethyl]-N-methylamino]butyl]-N''-[3-[3-(piperidinomethyl)phenoxy]propyl]guanidine 
• 149841-57-6 N-cyano-N'-[6-[N-[2-[N-(4-methoxybenzyl)-N-(2-pyridyl)amino]ethyl]-N-methylamino]hexyl]-N''-[3-[3-(piperidinomethyl)phenoxy]propyl]guanidine 
• 149841-76-9 N-cyano-N'-[2-[[(2-guanidino-4-thiazolyl)methyl]thio]ethyl]-N''-[2-[N-[2-[N-(4-methoxybenzyl)-N-(2-pyridyl)amino]ethyl]-N-methylamino]ethyl]guanidine 
• 149867-77-6 N-cyano-N'-[2-[[(2-guanidino-4-thiazolyl)methyl]thio]ethyl]-N''-[3-[N-[2-[N-(4-methoxybenzyl)-N-(2-pyridyl)amino]ethyl]-N-methylamino]propyl]guanidine 
• 149841-77-0 N-cyano-N'-[2-[[(2-guanidino-4-thiazolyl)methyl]thio]ethyl]-N''-[4-[N-[2-[N-(4-methoxybenzyl)-N-(2-pyridyl)amino]ethyl]-N-methylamino]butyl]guanidine 
• 149841-78-1 N-cyano-N'-[2-[[(2-guanidino-4-thiazolyl)methyl]thio]ethyl]-N''-[6-[N-[2-[N-(4-methoxybenzyl)-N-(2-pyridyl)amino]ethyl]-N-methylamino]hexyl]guanidine 
• 149867-80-1 N-cyano-N'-[3-[N-[2-[N-(4-methoxybenzyl)-N-(2-pyridyl)amino]ethyl]-N-methylamino]propyl]-N''-[2-[[5-(dimethylaminomethyl)furfuryl]thio]ethyl]guanidine 
• 562847-59-0 ({2-[(4-methoxy-benzyl)-pyridin-2-yl-amino]-ethyl}-methyl-amino)-acetonitrile 
• 1600520-50-0 C₁₉H₂₄N₄O 
• 562847-60-3 4-({2-[(4-methoxy-benzyl)-pyridin-2-yl-amino]-ethyl}-methyl-amino)-butyronitrile 
• 109912-36-9 N-[2-[N-(4-methoxybenzyl)-N-(pyridin-2-yl)amino]ethyl]-N-methyl-1,2-ethanediamine 
• 104499-47-0 N-Desmethylpyrilamine 

Relevant articles and documents

Synthesis and dual histamine H1 and H2 receptor antagonist activity of cyanoguanidine derivatives

Premedication with a combination of histamine H1 receptor (H1R) and H2 receptor (H2R) antagonists has been suggested as a prophylactic principle, for instance, in anaesthesia and surgery. Aiming at pharmacological hybrids combining H1R and H2R antagonistic activity, a series of cyanoguanidines 14-35 was synthesized by linking mepyramine-type H1R antagonist substructures with roxatidine-, tiotidine-, or ranitidine-type H2R antagonist moieties. N-desmethylmepyramine was connected via a poly-methylene spacer to a cyanoguanidine group as the "urea equivalent" of the H2R antagonist moiety. The title compounds were screened for histamine antagonistic activity at the isolated ileum (H1R) and the isolated spontaneously beating right atrium (H2R) of the guinea pig. The results indicate that, depending on the nature of the H2R antagonist partial structure, the highest H1R antagonist potency resided in roxatidine-type compounds with spacers of six methylene groups in length (compound 21), and tiotidine-type compounds irrespective of the alkyl chain length (compounds 28, 32, 33), N-cyano-N'-[2-[[(2- guanidino-4-thiazolyl)methyl] thio]ethyl]-N″-[2-[N-[2-[N-(4-methoxybenzyl)-N-(pyridyl)-amino] ethyl]-N-methylamino]ethyl] guanidine (25, pKB values: 8.05 (H1R, ileum) and 7.73 (H2R, atrium) and the homologue with the mepyramine moiety connected by a six-membered chain to the tiotidine-like partial structure (compound 32, pKB values: 8.61 (H1R) and 6.61 (H2R) were among the most potent hybrid compounds. With respect to the development of a potential pharmacotherapeutic agent, structural optimization seems possible through selection of other H1R and H2R pharmacophoric moieties with mutually affinity-enhancing properties.