109916-68-9Relevant academic research and scientific papers
Stereochemical Aspects of the Bose Reaction for α-Amino-β-lactam Synthesis
Manhas, Maghar S.,Veen, James M. van der,Wagle, Dilip R.,Hegde, Vinod R.,Bari, Shamsher S.,et al.
, p. 1095 - 1104 (2007/10/02)
Stereochemical aspects of the Bose reaction (formation of α-azido-β-lactams from an activated form of azidoacetic acid and imino compounds in the presence of a base) are examined.Substituted β-lactams prepared by stereocontrolled synthesis (including enantiospecific synthesis) are shown to be useful intermediates for β-lactam antibiotics, sugars, alkaloids and other natural products.A stereospecific synthesis of an optically active 3-aminosugar related to gentosamine starting from a β-lactam synthon is described.
