109923-50-4

Usage

Uses

Adenosine-2-d1 (CAS# 109923-50-4) is a useful isotopically labeled research compound.

Upstream product

• 920-42-3 dideuterioformic acid 
• 109923-44-6 5-Amino-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamidine Hydrochloride 
• 109923-49-1 1-(Formyl-d)-2(1H)-pyridone 
• 24808-47-7 5-Amino-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamidine 
• 71724-30-6 1-methoxy adenosine 
• 15763-11-8 2-hydrazinoadenosine 
• 35109-88-7 2-iodoadenosine 
• 110526-61-9 5-Amino-N'-methoxy-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamidine 
• 50663-83-7 5-Amino-4-(imidazol-2''-yl)-1-(β-D-ribofuranosyl)-1H-imidazole 
• 109923-44-6 C₉H₁₅N₅O₄*Cl^(1-) 
• 144216-36-4 C₁₂H₁₂⁽²⁾HN₅O₄ 

Downstream Products

• 109923-52-6 Adenine-2-d 

Relevant academic research and scientific papers

A newly devised method for the oxidative unmasking of 1,N6-etheno-adenosines: Facile conversion of adenosine into 2-deuterated adenosine

2-Deuterated adenosine (5) was conveniently prepared from adenosine (1) by applying the ring-fission and reclosure methodology of 1,N6-ethenoadenosine (2) and a new oxidative unmasking method of the etheno moiety.

Efficient synthesis of nebularine and vidarabine via dehydrazination of (hetero)aromatics catalyzed by CuSO4 in water

A simple dehydrazination reaction has been achieved in the presence of a catalytic amount of CuSO4 for the first time. With CuSO4 (2 mol%) as a catalyst and water as a solvent, the dehydrazination products were obtained in good yields (66-95%). Moreover, the drugs nebularine and vidarabine were afforded successfully, and vidarabine could be produced on a 0.923 kg scale, which shows good potential for industrial applications.

A NEW SYNTHETIC ROUTE TO 2-DEUTERIOADENINES SUBSTITUTED OR UNSUBSTITUTED AT THE 9-POSITION

9-alkyl-2-deuterioadenines (VIII b-d) , adenosine-2-d (VIIIe), and 2'-deoxyadenosine-2-d (VIIIf) were synthesized from the 9-substituted adenines Ib-f through cyclization of the monocyclic intermediates VIb-f with formic acid-d2 or 1-(formyl-d)-2-(1H)-pyridone.Hydrolysis of VIIIe, prepared through this synthetic route, with 0.5 N aqueous HCl ( reflux, 2h) gave adenine-2-d (VIIIa) in 77percent yield.Unambiguous assigments of the purine ring protons in the NMR spectra of the unlabeled adenines Ia-f have been made by comparison with those of the labeled adenines VIIIa-f.