109925-83-9Relevant academic research and scientific papers
Diels-Alder cycloaddition of vinylpyrazoles. Synergy between microwave irradiation and solvent-free conditions
Diaz-Ortiz, Angel,Carrillo, Jose R.,Diez-Barra, Enrique,De La Hoz, Antonio,Gomez-Escalonilla, Maria J.,Moreno, Andres,Langa, Fernando
, p. 9237 - 9248 (1996)
When subjected to microwave irradiation and solvent-free conditions vinylpyrazoles undergo Diels-Alder cycloadditions within 6-30 min to give acceptable yields of easily purified products. This methodology overcomes the most important disadvantages of the classical conditions and it permits the reaction to be extended to low reactive dienophiles, such as ethyl phenylpropiolate, not described by classical heating. The regiochemistry of the later reaction has been inferred by NOE experiments and molecular orbital calculations.
NEW CYCLOADDITION REACTIONS OF 1-PHENYL-4-VINYLPYRAZOLE
Simon, Mercedes Medio,Arques, Jose Sepulveda
, p. 6683 - 6686 (2007/10/02)
1-Phenyl-4-vinylpyrazole reacts with methyl propiolate and N-phenylmaleimide giving via the Diels-Alder 1:1 adducts, products (4) and (8), and also the 1:2 adducts (5), (6) and (9) resulting from an "ene" reaction of the initially formed cycloadducts.The
