109929-42-2

Upstream product

• 150-13-0 4-amino-benzoic acid 
• 3171-45-7 4,5-dimethyl-1,2-phenylenediamine 
• 62-23-7 4-nitro-benzoic acid 

Downstream Products

• 109929-46-6 C₃₈H₃₀N₃⁽¹⁺⁾*BF₄^(1-) 

Relevant academic research and scientific papers

Efficient synthesis of benzimidazoles containing 1,2,4-triazol-3-one nucleus using microwave technique

A series of new compounds containing both benzimidazole and 1,2,4-triazol-3-one rings was synthesized by microwave irradiation of mixtures containing 5-(alkyl/phenyl)-4-(4-carboxyphenyl)-2,4-dihydro-3H-1,2,4-triazol-3-ones and 1,2-diaminobenzene derivatives. Also, benzimidazole derivatives were synthesized by the reaction of ethyl 2-(ethoxy(alkyl/phenyl)methylene)hydrazine-1-carboxylates with 2-aminobenzimidazole. A rapid and efficient combination of 1,2,4-triazol-3-one and benzimidazole ring systems was achieved for the first time in this study.

1-[4-(1H-Benzoimidazol-2-yl)-phenyl]-3-[4-(1H-benzoimidazol-2-yl)-phenyl] -urea derivatives as small molecule heparanase inhibitors

A novel class of 1-[4-(1H-benzoimidazol-2-yl)-phenyl]-3-[4-(1H- benzoimidazol-2-yl)-phenyl]-ureas are described as potent inhibitors of heparanase. Among them are 1,3-bis-[4-(1H-benzoimidazol-2-yl)-phenyl]-urea (7a) and 1,3-bis-[4-(5,6-dimethyl-1H-benzoimidazol-2-yl)-phenyl]-urea (7d), which displayed good heparanase inhibitory activity (IC50 0.075-0.27 μM). Compound 7a showed good efficacy in a B16 metastasis model.

(BENZIMIDAZOL-2-YL)-PHENYL-BENZYL-AMINE DERIVATIVES AND METHODS FOR INHIBITING HEPARANASE ACTIVITY

The present invention encompasses heparanase inhibitors, particularly to certain (benzimidazol-2-yl)-phenyl-benzyl-amine derivatives that inhibit heparanase, pharmaceutical compositions that contain the compounds, methods for making the compounds, and methods of treating heparanase-dependent diseases and conditions in mammals by administering a therapeutically effective amount of the compounds to the mammals.

Benzimidazole compounds for regulating IgE

This invention relates to a family of phenylbenzimidazole analogs, which are inhibitors of the IgE response to allergens. These compounds are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic.

Benzimidazole derivatives as modulators of IgE

This invention relates to a family of benzimidazole analogs, which are inhibitors of the IgF response to allergens. These compounds are useful in the treatment of allergy, asthma, or any diseases where IgE is pathogenic.

Benzimidazole compounds for regulating IgE

This invention relates to a family of phenylbenzimidazole analogs, which are inhibitors of the IgE response to allergens. These compounds are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic.

Benzimidazole derivatives as modulators of IgE

This invention relates to a family of diacyl benzimidazole analogs, which are inhibitors of the IgE response to allergens. These compounds are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic.

Azinium Azolate Inner Salts: Synthesis and Structural Studies

Ten mesomeric betaines of the pyridinium azolate class have been prepared from the corresponding pyridinium azole salts.Theoretical calculations (MNDO), experimental dipole moments (10 to 19 D), 1H and 13C NMR spectra, and X-ray structure of pyridinium benzimidazolate inner salts 3 and 17 have been used to determine the electronic and molecular structure of these compounds.