109933-73-5

Upstream product

• 1756-44-1 1,3-bis-(2-ethoxy-phenyl)-thiourea 
• 79-11-8 chloroacetic acid 
• 94-70-2 ortho-phenitidine 
• 105-39-5 chloroacetic acid ethyl ester 

Downstream Products

• 102750-14-1 3-(2-ethoxy-phenyl)-2-(2-ethoxy-phenylimino)-5-furfurylidene-thiazolidin-4-one 
• 96707-59-4 3-(2-ethoxy-phenyl)-2-(2-ethoxy-phenylimino)-thiazolidine-4,5-dione 5-phenylhydrazone 
• 114553-22-9 3-(2-ethoxy-phenyl)-2-(2-ethoxy-phenylimino)-thiazolidine-4,5-dione 5-p-tolylhydrazone 
• 102081-89-0 3-(2-ethoxy-phenyl)-2-(2-ethoxy-phenylimino)-1,1-dioxo-1λ⁶-thiazolidin-4-one 

Relevant academic research and scientific papers

Novel non-peptidic small molecule inhibitors of secreted aspartic protease 2 (SAP2) for the treatment of resistant fungal infections

Targeting secreted aspartic protease 2 (SAP2), a kind of virulence factor, represents a new strategy for antifungal drug discovery. In this report, the first-generation of small molecule SAP2 inhibitors was rationally designed and optimized using a structure-based approach. In particular, inhibitor 23h was highly potent and selective and showed good antifungal potency for the treatment of resistant Candida albicans infections.