109938-62-7Relevant academic research and scientific papers
Copper-catalyzed coupling of N -tosylhydrazones with amines: Synthesis of fluorene derivatives
Aziz, Jessy,Frison, Gilles,Gmez, Montserrat,Brion, Jean-Daniel,Hamze, Abdallah,Alami, Mouad
, p. 4498 - 4503 (2015/02/19)
An original formation of one C-N bond and one C-C bond on the same carbenic center has been developed. This approach involves a copper-catalyzed cross-coupling reaction between 2'-bromo-biaryl-N-tosylhydrazones and different amines leading to 9H-fluoren-9-amine derivatives. This reaction proceeds under mild conditions in glycerol, an inexpensive and environmentally friendly solvent, without adding any external ligand.
