109946-61-4Relevant academic research and scientific papers
A USEFUL CONSTRUCTION OF 4-SUBSTITUTED 1-ALKYLPIPERID-3-ONES
Swindell, Charles S.,Duffy, Ruth H.
, p. 3373 - 3377 (2007/10/02)
A potentially general construction of 4-substituted 1-alkylpiperid-3-ones is described which employs 3-methoxy-4-bromopyridine as the crucial reagent.This substance is coupled at C-4 with Grignard reagents through the Kumada reaction.The resulting pyridines are then N-alkylated and subsequently subjected to borohydride reduction and aqueous acidic hydrolysis to reveal the title piperidones and related substances.
