1099589-75-9Relevant academic research and scientific papers
BENZOIMIDAZOLE DERIVATIVES AS ANTICANCER AGENTS
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Page/Page column 59; 61, (2018/04/20)
The invention relates to benzoimidazole derivatives, acting as anticancer drugs, as well as pharmaceutical composition containing said compounds. These compounds are able to firstly inhibit the protein/protein interactions of the MAP Kinase Erk, leading t
Antiviral activity of benzimidazole derivatives. II. Antiviral activity of 2-phenylbenzimidazole derivatives
Tonelli, Michele,Simone, Matteo,Tasso, Bruno,Novelli, Federica,Boido, Vito,Sparatore, Fabio,Paglietti, Giuseppe,Pricl, Sabrina,Giliberti, Gabriele,Blois, Sylvain,Ibba, Cristina,Sanna, Giuseppina,Loddo, Roberta,La Colla, Paolo
experimental part, p. 2937 - 2953 (2010/07/06)
Seventy-six 2-phenylbenzimidazole derivatives were synthesized and evaluated in cell-based assays for cytotoxicity and antiviral activity against a panel of 10 RNA and DNA viruses. The most commonly affected viruses were, in decreasing order, CVB-2, BVDV, Sb-1, HSV-1, and YFV, while HIV-1 and VSV were not affected, and RSV, VV and Reo-1 were only susceptible to a few compounds. Thirty-nine compounds exhibited high activity (EC50 = 0.1-10 μM) against at least one virus, and four of them were outstanding for their high and selective activity against VV (24, EC50 = 0.1 μM) and BVDV (50, 51, and 53 with EC50 = 1.5, 0.8, and 1.0 μM, respectively). The last compounds inhibited at low micromolar concentrations the NS5B RdRp of BVDV and also of HCV, the latter sharing structural similarity with the former. The considered compounds represent attractive leads for the development of antiviral agents against poxviruses, pestiviruses and even HCV, which are important human and veterinary pathogens.
Benzimidazole compounds for regulating IgE
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, (2008/06/13)
This invention relates to a family of phenylbenzimidazole analogs, which are inhibitors of the IgE response to allergens. These compounds are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic.
Benzimidazole compounds for regulating IgE
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, (2008/06/13)
This invention relates to a family of phenylbenzimidazole analogs, which are inhibitors of the IgE response to allergens. These compounds are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic.
Benzimidazole analogs as down-regulators of IgE
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, (2008/06/13)
This invention relates to a family of diacyl benzimidazole analogs, which are inhibitors of the IgE response to allergens. These compounds are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic.
