1099639-68-5Relevant articles and documents
Synthesis, DNA binding affinity and anticancer activity of novel 4: H -benzo [g] [1,2,3]triazolo[5,1- c] [1,4]oxazocines
Sastry, K. N. Visweswara,Routhu, Sunitha Rani,Datta, Soma Gupta,Nagesh, Narayana,Babu, Bathini Nagendra,Nanubolu, Jagadeesh Babu,Kumar, C. Ganesh,Maurya, Ram Awatar,Kamal, Ahmed
, p. 9294 - 9305 (2016)
A new class of tricyclic heterocycles 4H-benzo[g][1,2,3]triazolo[5,1-c][1,4]oxazocines was synthesized through a Knoevenagel condensation/azide-alkyne cycloaddition reaction cascade in one-pot operation. These eight membered ring containing heterocycles exhibited moderately high anticancer activity against four cancer cell lines; human cervix cancer cell line (HeLa), human prostate cancer cell line (DU145), human breast cancer cell line (MCF-7) and human breast adenocarcinoma epithelial cell line (MDA-MB-231). Our results indicate that these compounds have a weak cytotoxic effect on normal human mammary epithelial cell line (MCF-10A). Cell cycle and apoptosis assay indicate that they inhibit the cell cycle at the G2/M phase and induce apoptosis. Through the RED100 assay, it is evident that they have potential to inhibit pBR 322 plasmid DNA cleavage by BamH1. UV-visible, fluorescence titration and viscosity studies suggested that these compounds possess DNA binding affinity.
“On water” cascade synthesis of benzopyranopyrazoles and their macrocycles
Muthusamy, Sengodagounder,Gangadurai, Chinnakuzhanthai
supporting information, p. 1501 - 1505 (2018/03/21)
Reported herein is an intramolecular 1,3-dipolar cycloaddition strategy for rapid entry into benzopyranopyrazoles (BPP) on water medium as “open flask chemistry” approach. The in situ generation of diazo functionality in two-step sequence from the appropr
