1099644-42-4 Usage
Description
ITD-1 is a selective inhibitor of TGF-β signaling, which plays a crucial role in regulating various cellular processes, including cell growth, differentiation, and apoptosis. By targeting TGF-β signaling, ITD-1 has the potential to modulate these processes and impact various biological functions.
Uses
Used in Pharmaceutical Industry:
ITD-1 is used as a therapeutic agent for promoting cardiomyocyte differentiation in embryonic stem cells (ESCs). This application is particularly relevant for the treatment of heart diseases and regenerative medicine, as it can help in the development of new therapies to repair damaged heart tissue and improve cardiac function.
Additionally, ITD-1's ability to inhibit TGF-β signaling may have implications in other areas of medicine, such as cancer therapy, where TGF-β signaling is often implicated in tumor progression and metastasis. Further research is needed to explore the potential applications of ITD-1 in these areas.
Biological Activity
tgfβ signalling has been shown to be important at an early stage in cardiac development, with most previous investigations focussing on the role during formation of the cardiac cushions. these cushions, which develop between embryonic day e9.5 and e11.5 in the mouse, are essential precursors of the mature valves, and intimately involved in septation. it is well known that tgfβ signalling promotes endothelial to mesenchymal transition, and subsequent migration of mesenchymal cells to the cardiac jelly. itd-1 is the first selective tgfβ inhibitor.
in vitro
itd-1 has been used to evaluate tgfβ involvement in mesoderm formation and cardiopoietic differentiation, which occur sequentially during early development, indicating an essential role in both processes in esc cultures. itd-1 selectively enhanced the uncommitted mesoderm differentiation to cardiomyocytes, but not to vascular smooth muscle and endothelial cells. in summary, itd-1 is the first selective tgfβ inhibitor and reveals an unexpected role for tgfβ signaling in controlling the differentiation of cardiomyocyte from multipotent cardiovascular precursors [1].
references
[1] willems e, cabral-teixeira j, schade d, cai w, reeves p, bushway pj, lanier m, walsh c, kirchhausen t, izpisua belmonte jc, cashman j, mercola m. small molecule-mediated tgf-β type ii receptor degradation promotes cardiomyogenesis in embryonic stem cells. cell stem cell. 2012 aug 3;11(2):242-52.
Check Digit Verification of cas no
The CAS Registry Mumber 1099644-42-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,9,9,6,4 and 4 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1099644-42:
(9*1)+(8*0)+(7*9)+(6*9)+(5*6)+(4*4)+(3*4)+(2*4)+(1*2)=194
194 % 10 = 4
So 1099644-42-4 is a valid CAS Registry Number.
1099644-42-4Relevant articles and documents
Synthesis, characterization and heterogeneous catalytic application of a nickel(II) Schiff base complex immobilized on MWCNTs for the Hantzsch four-component condensation
Rakhtshah, Jamshid,Salehzadeh, Sadegh,Zolfigol, Mohammad Ali,Baghery, Saeed
, p. 340 - 360 (2017)
A nickel(II) Schiff base complex immobilized on multi-wall carbon nanotubes (MWCNTs) surface as a highly efficient heterogeneous catalyst was synthesized and characterized by IR, X-ray diffraction patterns, scanning electron microscopy, energy-dispersive
Four-component synthesis of polyhydroquinolines under catalyst- and solvent-free conventional heating conditions: mechanistic studies
Mayurachayakul, Pipattra,Pluempanupat, Wanchai,Srisuwannaket, Choladda,Chantarasriwong, Oraphin
, p. 56764 - 56770 (2017/12/27)
A convenient and environmentally friendly procedure for the synthesis of polyhydroquinolines via a one-pot, four component condensation of different aromatic aldehydes with dimedone, ethyl acetoacetate and ammonium acetate has been developed. Upon heating
Thermally reversible solidification of novel ionic liquid [im]HSO4 by self-nucleated rapid crystallization: Investigations of ionic conductivity, thermal properties, and catalytic activity
Bielejewski, Micha?,Ghorbani, Mahdi,Zolfigol, Mohammad Ali,Tritt-Goc, Jadwiga,Noura, Soheila,Narimani, Mahdi,Oftadeh, Mohsen
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In recent years, the growing concern for the environment has triggered the search for new materials that meet the criteria for the preservation of natural habitats. Among these materials are ionic liquids, the new generation of which has contributed subst
