1099654-08-6Relevant academic research and scientific papers
Al(OTf)3-Catalyzed Preparation of 4-Hydroxy-3-propargylic Coumarins and Subsequent Regioselective Cyclization towards Furo- or Pyrano[3,2-c]coumarins
Ponra, Sudipta,Gohain, Mukut,Van Tonder, Johannes H.,Bezuidenhoudt, Barend C.B.
supporting information, p. 745 - 750 (2015/03/30)
An efficient and economical approach to functionalized furo[3,2-c]coumarin and pyrano[3,2-c]coumarin derivatives has been developed from 4-hydroxy-3-(prop-2-ynyl)coumarin derivatives through organocatalysis or metallo-organocatalysis. Selective '5-exo-dig
Solid-supported acid-catalyzed C3-alkylation of 4-hydroxycoumarins with secondary benzyl alcohols: access to 3,4-disubstituted coumarins via Pd-coupling
Reddy, Ch. Raji,Srikanth,Narsimha Rao,Shin, Dong-Soo
experimental part, p. 11666 - 11672 (2009/04/11)
An efficient and operationally simple method for C3-alkylation of 4-hydroxycoumarins has been developed under acidic medium giving good yields of the products. In the present method, a reusable Amberlite IR-120 (H+ form) was used as an acid catalyst and secondary benzyl alcohols were used as alkylating agents. The obtained 3-alkylated-4-hydroxycoumarins offered an easy access for the synthesis of 3,4-disubstituted coumarins by way of Pd-catalyzed coupling reactions.
