1099654-14-4Relevant academic research and scientific papers
Condensation of propargylic alcohols with 1,3-dicarbonyl compounds and 4-hydroxycoumarins in ionic liquids (ILs)
Aridoss, Gopalakrishnan,Laali, Kenneth K.
supporting information; experimental part, p. 6859 - 6864 (2012/02/05)
Propargylic alcohols are activated toward 1,3-diketones by Lewis or Br?nsted acidic ionic liquids (ILs) without an added catalyst, but significantly better conversions are achieved with metallic triflates [in particular Sc(OTf)3 and Ln(OTf)sub
Solid-supported acid-catalyzed C3-alkylation of 4-hydroxycoumarins with secondary benzyl alcohols: access to 3,4-disubstituted coumarins via Pd-coupling
Reddy, Ch. Raji,Srikanth,Narsimha Rao,Shin, Dong-Soo
experimental part, p. 11666 - 11672 (2009/04/11)
An efficient and operationally simple method for C3-alkylation of 4-hydroxycoumarins has been developed under acidic medium giving good yields of the products. In the present method, a reusable Amberlite IR-120 (H+ form) was used as an acid catalyst and secondary benzyl alcohols were used as alkylating agents. The obtained 3-alkylated-4-hydroxycoumarins offered an easy access for the synthesis of 3,4-disubstituted coumarins by way of Pd-catalyzed coupling reactions.
