1099752-11-0Relevant academic research and scientific papers
Cobalt-Catalyzed Regio- and Enantioselective Allylic Amination
Ghorai, Samir,Chirke, Sahadev Shrihari,Xu, Wen-Bin,Chen, Jia-Feng,Li, Changkun
supporting information, p. 11430 - 11434 (2019/08/20)
The first earth-abundant cobalt-catalyzed highly branched- and enantioselective allylic amination of racemic branched allylic carbonates bearing alkyl groups with both aromatic and aliphatic amines has been developed. The process allows rapid access of allylic amines in high yields with exclusively branched selectivity and excellent enantioselectivities (normally 99% ee) under mild reaction conditions.
Enantioselective iridium-catalyzed allylic aminations of allylic carbonates with functionalized side chains. Asymmetric total synthesis of (S)-vigabatrin
Gnamm, Christian,Franck, Geraldine,Miller, Nicole,Stork, Timon,Broedner, Kerstin,Helmchen, Guenter
experimental part, p. 3331 - 3350 (2009/05/27)
Indium-catalyzed aminations of allylic carbonates containing a variety of O-functional groups have been explored. High degrees of regio- as well as enantioselectivity were achieved with diacylamides under salt-free conditions and with arylamines. The results allowed the antiepilepsy drug (5)-vigabatrin to be prepared via a very short route.
