1100-22-7

Basic information

• Product Name: DANSYL-L-LEUCINE
• Synonyms: DANSYL-L-LEUCINE;5-DIMETHYLAMINONAPHTHALENE-1-SULFONYL-L-LEUCINE;Dansylleucine;DANSYL-L-LEUCINE 98+%;Dns-Leu-OH;(S)-2-[[[5-(Dimethylamino)-1-naphthalenyl]sulfonyl]amino]-4-methylvaleric acid;N-[[5-(Dimethylamino)-1-naphthalenyl]sulfonyl]-L-leucine;N-[5-(Dimethylamino)-1-naphtylsulfonyl]leucine
• CAS NO: 1100-22-7
• Molecular Formula: C₁₈H₂₄N₂O₄S
• Molecular Weight: 364.46
• Product Categories: Amino Acids;Amino Acids (N-Protected);Biochemistry;Dansyl Amino Acids
• Mol File: 1100-22-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 126 °C
• Boiling Point: 545°Cat760mmHg
• Flash Point: 283.4°C
• Appearance: /
• Density: 1.256g/cm³
• Refractive Index: -9.5 ° (C=1, EtOH)
• CAS DataBase Reference: DANSYL-L-LEUCINE(CAS DataBase Reference)
• NIST Chemistry Reference: DANSYL-L-LEUCINE(1100-22-7)
• EPA Substance Registry System: DANSYL-L-LEUCINE(1100-22-7)

Safety Data

• Hazardous Substances Data: 1100-22-7(Hazardous Substances Data)

Usage

General Description

DANSYL-L-LEUCINE is a chemical compound that consists of a dansyl fluorophore attached to the amino acid leucine. It is commonly used as a probe in studies of enzyme kinetics, protein folding, and peptide binding. The dansyl group emits strong fluorescence when excited by ultraviolet light, and this property makes DANSYL-L-LEUCINE a valuable tool for monitoring and quantifying the interactions and activities of proteins and enzymes. Additionally, the leucine moiety provides a specific binding site for the compound, allowing researchers to study the behavior of leucine-containing peptides and proteins in biological systems. Overall, DANSYL-L-LEUCINE is a versatile chemical tool that is frequently employed in biochemical and biophysical research.

Upstream product

• 65452-14-4 dansyl-D,L-leucine 

Relevant articles and documents

Preparation and evaluation of a triazole-bridged bis(β-cyclodextrin)–bonded chiral stationary phase for HPLC

A triazole-bridged bis(β-cyclodextrin) was synthesized via a high-yield Click Chemistry reaction between 6-azido-β-cyclodextrin and 6-propynylamino-β-cyclodextrin, and then it was bonded onto ordered silica gel SBA-15 to obtain a novel triazole-bridged bis (β-cyclodextrin)–bonded chiral stationary phase (TBCDP). The structures of the bridged cyclodextrin and TBCDP were characterized by the infrared spectroscopy, mass spectrometry, elemental analysis, and thermogravimetric analysis. The chiral performance of TBCDP was evaluated by using chiral pesticides and drugs as probes including triazoles, flavanones, dansyl amino acids and β-blockers. Some effects of the composition in mobile phase and pH value on the enantioseparations were investigated in different modes. The nine triazoles, eight flavanones, and eight dansyl amino acids were successfully resolved on TBCDP under the reversed phase with the resolutions of hexaconazole, 2′-hydroxyflavanone, and dansyl-DL-tyrosine, which were 2.49, 5.40, and 3.25 within 30 minutes, respectively. The ten β-blockers were also separated under the polar organic mode with the resolution of arotinolol reached 1.71. Some related separation mechanisms were discussed preliminary. Compared with the native cyclodextrin stationary phase (CDSP), TBCDP has higher enantioselectivity to separate more analytes, which benefited from the synergistic inclusion ability of the two adjacent cavities and bridging linker of TBCDP, thereby enabling it a promising prospect in chiral drugs and food analysis.

Chiral separation of enantiomers of amino acid derivatives by HPLC on vancomycin and teicoplanin chiral stationary phases

The chiral separation of α-amino acids by liquid chromatography using macrocyclic antibiotic bonded stationary phases were studied. Teicoplanin and vancomycin bonded stationary phases have been used to separate enantiomers of dansyl amino acids in the reversed - phase high performance liquid chromatography mode. By comparison of chromatographic parameters obtained by use of both chiral stationary phases it the mechanism of chiral separation could be suggested. The better separation - greater value of R(j,i) of enantiomers - was achieved by the teicoplanin column.