1100-88-5Relevant articles and documents
Corrosion inhibition of magnesium alloy in NaCl solution by ionic liquid: Synthesis, electrochemical and theoretical studies
Su, Huishuang,Liu, Yue,Gao, Xing,Qian, Yafeng,Li, Weijie,Ren, Tiegang,Wang, Li,Zhang, Jinglai
, p. 681 - 689 (2019)
A new ionic liquid, benzyl triphenyl phosphonium bis(trifluoromethylsulfonyl)amide ([BPP][NTf2]), for magnesium alloy is synthesized. The potential of [BPP][NTf2] to be inhibitor is firstly estimated as compared with [P6,6,6,14][NTf2] by theoretical calculations. Then, the inhibition of AZ31B Mg alloy in 0.05 wt% NaCl solution is evaluated by [BPP][NTf2] is investigated by Tafel linear polarization method, electrochemical impedance spectroscopy (EIS), and scanning electron microscopy (SEM). The most optimum inhibitor efficiency of [BPP][NTf2] is 91.4% at room temperature. The adsorption of [BPP][NTf2] on the surface of AZ31B Mg alloy obeys Langmuir isotherm with predominantly chemical adsorption. The corresponding result is further analyzed by the theory. The corrosive product is detected by Fourier transform infrared spectrum (FTIR). The possible inhibition mechanism is proposed, in which the effect of cation on inhibition is proposed in addition to the influence of anion.
Arylmethyloxyphenyl derivatives: Small molecules displaying P-glycoprotein inhibition
Colabufo, Nicola Antonio,Berardi, Francesco,Perrone, Roberto,Rapposelli, Simona,Digiacomo, Maria,Balsamo, Aldo
, p. 6607 - 6613 (2006)
Some arylmethyloxyphenyl derivatives were prepared as simplified structures of analogous arylpiperazines with high affinity toward dopaminergic D 2 and serotonergic 5-HT1A receptors and inhibiting P-glycoprotein (P-gp). The compounds 5b and 8b displayed good P-gp inhibition activity measured as [3H]vinblastine transport inhibition in the Caco-2 cell monolayer and intracellular doxorubicin accumulation in MCF7/Adr cells by flow cytometry. Compounds 5b and 8b also inhibited, dose-dependently, ATP-ase activation induced by P-gp substrate vinblastine.
Preparation of fat-liquor based on jojoba oil under phase transfer catalysis
Nashy, El-Shahat H. A.,Megahed,Abd El-Ghaffar
, p. 1239 - 1246 (2011)
Jojoba oil is of immense importance for industrial applications. There are a lot of published articles concerning its various uses in cosmetics, detergents, surfactants and lubricants. Therefore, this work was devoted to exploring its application for further use in the leather industry as a fat-liquoring agent. The fat-liquoring process is one important step in leather manufacturing, with the intention of obtaining leather of full, soft handle, flexibility, and pliability as well as improving its mechanical properties. The study involved preparation of jojoba fat-liquor via a sulfitation process. An improvement of the sulfitation process based on combined SO3 content was achieved under phase transfer catalysis (PTC). Two differently prepared types of phase transfer catalyst of phosphonium and ammonium types were investigated, namely, benzyl tri-phenyl phosphonium chloride (BTPP) and tri-ethyl benzyl ammonium chloride (TEBA). The fat-liquored leather led to an improvement in its mechanical properties such as tensile strength and elongation at break. In addition, a significant enhancement of the texture of the treated leather by jojoba fat-liquor as indicated in the scanning electron microscope (SEM) images was observed.
Structure-Activity-Relationship-Aided Design and Synthesis of xCT Antiporter Inhibitors
Cirillo, Davide,Sarowar, Shahin,?yvind Enger, Per,Bj?rsvik, Hans-René
, p. 2650 - 2668 (2021/06/01)
The xCT antiporter is a cell membrane protein involved in active counter-transportation of glutamate (outflux) with cystine (influx) over the human cell membrane. This feature makes the xCT antiporter a crucial element of the biosynthesis of the vital free radical scavenger glutathione. The prodrug sulfasalazine, a medication for the treatment of ulcerative colitis, was previously proven to inhibit the xCT antiporter. Starting from sulfasalazine, a molecular scaffold jumping followed by SAR-assisted design and synthesis provided a series of styryl hydroxy-benzoic acid analogues that were biologically tested in vitro for their ability to decrease intracellular glutathione levels using four different cancer cell lines: A172 (glioma), A375 (melanoma), U87 (glioma) and MCF7 (breast carcinoma). Depletion of glutathione levels varied among the compounds as well as among the cell lines. Flow cytometry using propidium iodide and the annexin V marker demonstrated minimal toxicity in normal human astrocytes for a promising candidate molecule (E)-5-(2-([1,1′-biphenyl]-4-yl)vinyl)-2-hydroxybenzoic acid.
Chiral Imidodiphosphoric Acid-Catalyzed Highly Diastereo- and Enantioselective Synthesis of Poly-Substituted 3,4-Dihydro-2 H-pyrans: [4 + 2] Cycloadditions of β,γ-Unsaturated α-Ketoesters and 3-Vinylindoles
Guan, Xu-Kai,Liu, Guo-Feng,An, Dong,Zhang, Heng,Zhang, Suo-Qin
supporting information, p. 5438 - 5442 (2019/08/01)
Imidodiphosphoric acids were employed to catalyze inverse-electron-demand hetero-Diels-Alder reaction of β,γ-unsaturated α-ketoesters and 3-vinylindoles. A series of optically active 3,4-dihydro-2H-pyran derivatives with three contiguous stereogenic centers was synthesized in excellent yields (70-99%), diastereoselectivities (>20:1), and enantioselectivities (73-99%). The resulting indole containing 3,4-dihydro-2H-pyran could be converted to tetrahydropyran derivatives, which appear in several biological active compounds by simple hydrogenation reduction.
Long sought synthesis of quaternary phosphonium salts from phosphine oxides: Inverse reactivity approach
Vetter, Anna C.,Nikitin, Kirill,Gilheany, Declan G.
, p. 5843 - 5846 (2018/06/13)
Quaternary phosphonium salts (QPS), a key class of organophosphorus compounds, have previously only been available by routes involving nucleophilic phosphorus. We report the realisation of the opposite approach to QPS utilising phosphine oxides as the electrophilic partner and Grignard reagents as nucleophiles. The process is enabled through the crucial intermediacy of the derived halophosphonium salts. The route does not suffer from the slow kinetics and limited availability of many parent phosphines and a broad range of QPS were prepared in excellent yields.
Synthesis of aryl and heterocyclic polyenes and their activity in free radical scavenging
Deng, Kaini,Yang, Zuxing,Luo, Juan,Wu, Kaiqun
, p. 129 - 132 (2018/04/20)
Aryl polyenes and heterocyclic polyenes with the same central C20 unit of β,β-carotene but different terminal groups were synthesised. Their free radical scavenging activity was measured by a 1,1-diphenyl-2-picrylhydrazinyl spectrophotometric method. The results indicated that all the new compounds have free radical scavenging activity.
Ionic Liquids as Solvents for SN2 Processes. Demonstration of the Complex Interplay of Interactions Resulting in the Observed Solvent Effects
Schaffarczyk McHale, Karin S.,Haines, Ronald S.,Harper, Jason B.
, p. 1162 - 1168 (2019/01/04)
Bimolecular nucleophilic substitution reactions between triphenylphosphine and benzylic electrophiles have been examined in an ionic liquid to probe interactions with species along the reaction coordinate. Trends in the rate constant were found on both varying the leaving group and the electronic nature of the aromatic ring. In all the cases considered, interactions between the components of the ionic liquid and the transition state were shown to be more significant in determining reaction outcome than previously observed for this class of reaction. This demonstrates the importance of considering interactions of the ionic liquid components with all species along the reaction coordinate when investigating the origin of ionic liquid solvent effects, along with how such effects might be exploited.
Benzofuran compound and its preparation, use (by machine translation)
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Paragraph 0057-0058, (2017/08/18)
The invention relates to a benzofuran compound and its preparation, use, its structural formula such as formula (I) as shown: Wherein R1 , R2 , R4 Are selected from hydrogen, C1 - C5 Alkyl, nitro, halogen, ester, hydroxy, amino, amide base or alkoxyl; R3 Hydrogen, C1 - C5 Alkyl, benzyl, aromatic or heteroaromatic group. The invention also relates to the benzofuran compounds in inhibiting the application of gram-positive to be used repeatedly. The invention relates to 3 - oxime substituted benzene and furan structure aromatic ring as the center, the establishment and optimize the preparation method of the compound, and on the preparation of novel compound of the bacteriostatic screening experiment, through initial bacteriostatic test to confirm that preparation compound has broad-spectrum bacteriostatic activity. (by machine translation)
One-pot synthesis of 2,4,5-trisubstituted imidazole derivatives catalyzed by BTPPC under solvent-free conditions
Alikarami, Mohammad,Amozad, Mozhgan
, p. 177 - 184 (2017/07/24)
A simple and efficient method for one-pot synthesis of lophine derivatives (2,4,5-trisubstituted imidazoles) by using the benzyltriphenylphosphonium chloride (BTPPC), as a catalyst, under solvent-free conditions is described. BTPPC is an available and inexpensive catalyst; also, it can be easily supplied. This procedure led to the corresponding 2,4,5-trisubstituted imidazoles products in high yields.
