110005-28-2

Basic information

• Product Name: (2S-cis)-4-(dicyclohexylphosphinyl)-2-<(diphenylphosphinyl)-methyl>pyrrolidine
• CAS NO: 110005-28-2
• Molecular Weight: 497.598
• Mol File: 110005-28-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2S-cis)-4-(dicyclohexylphosphinyl)-2-<(diphenylphosphinyl)-methyl>pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (2S-cis)-4-(dicyclohexylphosphinyl)-2-<(diphenylphosphinyl)-methyl>pyrrolidine(110005-28-2)
• EPA Substance Registry System: (2S-cis)-4-(dicyclohexylphosphinyl)-2-<(diphenylphosphinyl)-methyl>pyrrolidine(110005-28-2)

Safety Data

• Hazardous Substances Data: 110005-28-2(Hazardous Substances Data)

Upstream product

• 1079-66-9 chloro-diphenylphosphine 
• 110005-26-0 (2S-cis)-4-(dicyclohexylphosphinyl)-2-<(diphenylphosphinyl)-methyl>-1-(methylsulfonyl)-2-pyrrolidine 
• 4376-01-6 sodium diphenylphosphide 
• 110005-25-9 (2S-cis)-4-(dicyclohexylphosphinyl)-1-(methylsulfonyl)-2-pyrrolidinemethanol methanesulfonate 
• 110005-18-0 (2S-trans)-4-hydroxy-1-(methylsulfonyl)-2-pyrrolidinecarboxylic acid ethyl ester 
• 110005-19-1 (2S-trans)-4-hydroxy-1-(methylsulfonyl)-2-pyrrolidinemethanol 
• 33996-30-4 trans-4-hydroxy-L-proline ethyl ester hydrochloride 

Downstream Products

• 110450-63-0 (2S,4S)-2-[(Dicyclohexylphosphanyl)-methyl]-4-diphenylphosphanyl-pyrrolidine 
• 112522-02-8 (2S,4S)-4-dicyclohexylphosphino-2-diphenylphosphinomethylpyrrolidine 
• 110005-29-3 (2S,4S)-N-(phenyl-carbamoyl)-4-(dicyclohexylphosphino)-2-<(diphenylphosphino)methyl>pyrrolidine 
• 110005-30-6 (2S,4S)-N-(t-butoxycarbonyl)-4-(dicyclohexylphosphino)-2-[(diphenylphosphino)methyl]pyrrolidine 

Relevant articles and documents

Preparations of chiral pyrrolidinebisphosphines bearing two different types of phosphino groups and their use in efficient catalytic asymmetric hydrogenation

Chiral pyrrolidinebisphosphine ligands, (2S-cis)-BCPM and (2S-cis)-BCPP, bearing two different types of phosphino groups, a dicyclohexylphosphino group and a diphenylphosphino group, were designed and prepared on the basis of our design concept for developing highly efficient ligands. The validity of the concept was confirmed experimentally in the asymmetric hydrogenation of ketopantolactone using neutral rhodium(I) complexes of BCPM. BCPP, BPPM, and BCCP. The rhodium(I) complex of (2S-cis)-BCPM was found to be the most effective catalyst (substrate/catalyst >ca. 104, >90% ee (R)).