110043-77-1Relevant articles and documents
Synthesis and in vitro antibacterial activity of four novel pleuromutilin derivatives
Tang, Youzhi,Luo, Jian,Chen, Xiaojie,Wang, Bo,Shen, Xiangguang,Liu, Jianhua
, p. 1537 - 1540 (2013)
Four novel pleuromutilin derivatives with butyl amine group in the C-14 side-chain were designed, synthesized and confirmed by FT-IR, 1H-NMR and HRMS. The results of antibacterial activity showed that the antibacterial activity of pleuromutilin derivative
Inversion of Configuration of the Vinylgroup at Carbon 12 by Reversible Retro-En-Cleavage
Berner, Heinz,Vyplel, Hermann,Schulz, Gerhard,Schneider, Helmut
, p. 1073 - 1080 (2007/10/02)
The reaction of pleuromutilin-22-O-tosylat(2) with EtZnI afforded a mixture of the 12-epimeric compounds 2 and 3.A reversible retro-en-reaction of the homoallylic system is discussed as a possible mechanistic pathway.The structure assignment is based on 1H- and 13C-NMR spectroscopic data. - Keywords: Pleuromutilin; Inversion of configuration; Reversible retro-en-cleavage; Simmons-Smith-reaction; Type I-"metallo-en"-reaction