1100708-14-2

Upstream product

• 81000-30-8 2,4-dihydro-5-methyl-2-phenyl-4-(diphenylmethylene)-3H-pyrazol-3-one 
• 105-39-5 chloroacetic acid ethyl ester 

Downstream Products

• 1431540-84-9 ethyl 2-(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)-3,3-diphenylacrylate sodium salt 
• 1187037-76-8 ethyl 6-cyano-3-methyl-1,5,5-triphenyl-1,4,5,6-tetrahydropyrano[2,3-c]pyrazole-4-carboxylate 
• 1187037-65-5 ethyl 2-[5-(cyanomethoxy)-3-methyl-1-phenyl-1H-pyrazol-4-yl]-3,3-diphenylacrylate 
• 1187037-53-1 ethyl 2-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3,3-diphenylacrylate 

Relevant academic research and scientific papers

Chemical reactivity and application of 4-alkylidene-3H-pyrazol-3-ones: Synthesis and antifungal activity of polysubstituted pyrazoles

Chemical reactivity and application of 4-alkylidene-3H-pyrazol-3-ones are described. Furthermore, twelve of the newly synthesized O-substituted pyrazoles were evaluated for their antifungal activity in vitro against Candida albicans and Saccharomyces cere

Synthesis and antifungal activity of spiro[cyclopropane-1,4′-pyrazol- 3-one] derivatives

(Chemical Equation Presented) A series of new spiro[cyclopropane-1, 4′-pyrazol-3-one] derivatives 3a-h were synthesized by the reaction of 4-arylidene-3H-pyrazol-3-one 1 with secondary and tertiary carbanions derived from a methylene and methine group bearing both a leaving group and electron-withdrawing group, e.g. methyl chloroacetate, ethyl chloroacetate, isopropyl chloroacetate, tert-butyl chloroacetate, chloroacetonitrile, 2-chloro-N,N-diethylacetamide, methyl 2-chloropropionate and 2-chloropropionitrile, in the presence of sodium hydride. All the synthesized compounds 3a-h were active against Candida albicans with MIC ≥ 25 μg/mL in vitro.