1100718-99-7Relevant academic research and scientific papers
Design, synthesis, and evaluation of no-donor containing carbonic anhydrase inhibitors to lower intraocular pressure
Huang, Qinhua,Rui, Eugene Y.,Cobbs, Morena,Dinh, Dac M.,Gukasyan, Hovhannes J.,Lafontaine, Jennifer A.,Mehta, Saurabh,Patterson, Brian D.,Rewolinski, David A.,Richardson, Paul F.,Edwards, Martin P.
, p. 2821 - 2833 (2015)
The antiglaucoma drugs dorzolamide (1) and brinzolamide (2) lower intraocular pressure (IOP) by inhibiting the carbonic anhydrase (CA) enzyme to reduce aqueous humor production. The introduction of a nitric oxide (NO) donor into the alkyl side chain of do
INHIBITORS OF CARBONIC ANHYDRASE
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Page/Page column 31-32, (2009/03/07)
The invention relates to a compound of formula (I) and to pharmaceutically acceptable salts and solvates thereof. The invention also relates to methods of treating glaucoma, ocular hypertension, age-related macular degeneration, diabetic macular edema, di
