110073-82-0

Basic information

• Product Name: 1H-Indole-5-carboxylic acid, 2-phenyl-
• CAS NO: 110073-82-0
• Molecular Formula: C15H11NO2
• Molecular Weight: 237.258
• Mol File: 110073-82-0.mol

Chemical Properties

• CAS DataBase Reference: 1H-Indole-5-carboxylic acid, 2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-5-carboxylic acid, 2-phenyl-(110073-82-0)
• EPA Substance Registry System: 1H-Indole-5-carboxylic acid, 2-phenyl-(110073-82-0)

Safety Data

• Hazardous Substances Data: 110073-82-0(Hazardous Substances Data)

Usage

Derivative of indole

Heterocyclic aromatic organic compound

Synthesis applications

Widely used in pharmaceuticals, agrochemicals, and other organic compounds

Potential in drug discovery

Unique structure and pharmacological properties

Presence of phenyl group

Aromatic and hydrophobic nature

Suitability for chemical reactions

Due to its aromatic and hydrophobic nature

Diverse uses

Important chemical in chemistry and medicine fields

Upstream product

• 2122-63-6 4-amino-3-iodobenzoic acid 
• 150-13-0 4-amino-benzoic acid 
• 83813-70-1 indole-3,5-dicarboxylic acid 
• 144930-50-7 mesityl(phenyl)iodonium triflouromethanesulfonate 
• 190071-25-1 2-phenyl-1H-indole-5-carboxylic acid methyl ester 
• 190071-24-0 4-acetylamino-3-iodo-benzoic acid 
• 536-74-3 phenylacetylene 

Downstream Products

• 1258948-87-6 3,5-dinitrophenone-2-phenyl-5-indolecarboxylic acid 
• 1258948-84-3 3-nirophenone-2-phenyl-5-indolecarboxylic acid 
• 1258948-88-7 2-flurophenone-2-phenyl-5-indolecarboxylic acid 
• 1258948-86-5 4-aminophenone-2-phenyl-5-indolecarboxylic acid 
• 1258948-85-4 p-nirophenone-2-phenyl-5-indolecarboxylic acid 
• 1258948-83-2 C₂₂H₁₅NO₃ 
• 1154060-24-8 C₂₁H₁₇N₃O₅S₂ 

Relevant articles and documents

Solid-phase synthesis of indoles using the palladium-catalysed coupling of alkynes with iodoaniline derivatives

The solid-phase synthesis of indoles using Pd(0) catalysed coupling of alkynes with iodaniline derivatives is described. The reaction gives indoles in high yields with a wide range of alkynes.

Access to 2-Arylindoles via Decarboxylative C?C Coupling in Aqueous Medium and to Heteroaryl Carboxylates under Base-Free Conditions using Diaryliodonium Salts

Easily accessible heteroaromatic carboxylic acids and diaryliodonium salts were successfully employed to construct valuable 2-arylindoles and heteroaryl carboxylates in a regioselective fashion. C2-arylated indoles were produced using a Pd-catalyzed decarboxylative strategy in water without any base, oxidant, or ligand. Heteroaryl carboxylates were prepared under metal and base-free conditions. This protocol was successfully utilized to synthesize Paullone, a cyclin-dependent kinase (CDK) inhibitor.

BIS-(SULFONYLAMINO) DERIVATIVES IN THERAPY 065

The invention provides compounds of formula wherein R1, R2, R3, A and m are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of microsomal prostaglandin E synthase-1

BIS-(SULFONYLAMINO) DERIVATIVES IN THERAPY 066

The invention provides compounds of formula wherein R1, R3, L1, L2, G1, G2, A and m are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of microsomal prostaglandin E synthase-1.

Structure-activity relationships of 2-aryl-1H-indole inhibitors of the NorA efflux pump in Staphylococcus aureus

The synthesis of 22 2-aryl-1H-indoles, including 12 new compounds, has been achieved via Pd- or Rh-mediated methodologies, or selective electrophilic substitution. All three methods were based on elaborations from simple indole precursors. SAR studies on