1100767-82-5

Basic information

• Product Name: 1-[4-(morpholine-4-sulfonyl)-3-trifluoromethyl-phenyl]-ethylamine
• Synonyms: 1-[4-(morpholine-4-sulfonyl)-3-trifluoromethyl-phenyl]-ethylamine
• CAS NO: 1100767-82-5
• Molecular Weight: 338.351
• Mol File: 1100767-82-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-[4-(morpholine-4-sulfonyl)-3-trifluoromethyl-phenyl]-ethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4-(morpholine-4-sulfonyl)-3-trifluoromethyl-phenyl]-ethylamine(1100767-82-5)
• EPA Substance Registry System: 1-[4-(morpholine-4-sulfonyl)-3-trifluoromethyl-phenyl]-ethylamine(1100767-82-5)

Safety Data

• Hazardous Substances Data: 1100767-82-5(Hazardous Substances Data)

Upstream product

• 176225-10-8 4-bromo-2-(trifluoromethyl)benzene-1-sulfonyl chloride 
• 1100767-81-4 1-[4-(morpholine-4-sulfonyl)-3-trifluoromethyl-phenyl]-ethanone 

Downstream Products

• 1100769-10-5 N-(4-carbamimidoyl-phenyl)-N'-{(S)-1-[4-(morpholine-4-sulfonyl)-3-trifluoromethyl-phenyl]-ethyl}-malonamide trifluoroacetate 

Relevant articles and documents

MALONAMIDE DERIVATIVES WITH ANTITHROMBOTIC ACTIVITY

The present invention relates to compounds of the formula (I). The compounds of the formula (I) are valuable pharmacologically active compounds. They exhibit a strong anti-thrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardio-vascular disorders like thromboembolic diseases or restenoses. They are inhibitors of the blood clotting enzymes, especially factor VIla and can in general be applied in conditions in which an undesired activity of factor VIla is present or for the cure or prevention of which an inhibition of factor VIla is intended. The invention furthermore relates to processes for the preparation of compounds of the formula (I), their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.