1100767-90-5

Upstream product

• 79406-57-8 3-amino-4-chloroacetophenone 
• 351003-52-6 4-bromo-2-chlorobenzene-1-sulfonyl chloride 
• 351003-59-3 4-bromo-2-chlorobenzenesulfonamide 
• 97674-02-7 tributyl(1-ethoxyvinyl)stannane 

Downstream Products

• 1100767-91-6 4,N-diacetyl-2-chloro-benzenesulfonamide 
• 1100767-92-7 N-acetyl-4-(1-amino-ethyl)-2-chloro-benzenesulfonamide 
• 1100767-89-2 N-[1-(4-acetylsulfamoyl-3-chloro-phenyl)-ethyl]-N'-(4-carbamimidoyl-phenyl)-malonamide trifluoroacetate 

Relevant academic research and scientific papers

MALONAMIDE DERIVATIVES WITH ANTITHROMBOTIC ACTIVITY

The present invention relates to compounds of the formula (I). The compounds of the formula (I) are valuable pharmacologically active compounds. They exhibit a strong anti-thrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardio-vascular disorders like thromboembolic diseases or restenoses. They are inhibitors of the blood clotting enzymes, especially factor VIla and can in general be applied in conditions in which an undesired activity of factor VIla is present or for the cure or prevention of which an inhibition of factor VIla is intended. The invention furthermore relates to processes for the preparation of compounds of the formula (I), their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.

1-MERCAPTOACYL-3-[(AMINOSULFONYL)PHENYL]-4,5-DIHYDRO-1H-PYRAZOLE-5-CARBOXYLIC ACID

Compounds having the formula STR1 wherein R 1 is hydrogen, alkyl, aryl, arylalkyl or a hydrolyzable acyl protecting group; R 2 is hydrogen, alkyl or trifluoromethyl; R 3 and R 4 each is independently hydrogen, halogen, trifluoromethyl, alkylamino, furylmethylamino, phenylamino, thienylmethylamino, alkoxy, aryloxy, benzylthio, arylthio, benzyl, benzoyl, hydroxy, cyano or arylmethoxy; R 5 is hydrogen, alkyl or arylalkyl; andn is 0, 1 or 2, have hypotensive activity.