110078-47-2

Basic information

• Product Name: 1,4,8,11-Tetraazacyclotetradecane, 1,1'-[1,4-phenylenebis(Methylene)]bis[4,8,11-tris[(4-Methylphenyl)sulfon yl]-
• Synonyms: 1,4,8,11-Tetraazacyclotetradecane, 1,1'-[1,4-phenylenebis(Methylene)]bis[4,8,11-tris[(4-Methylphenyl)sulfon yl]-;1,1'-[1,4-Phenylenebis(methylene)]bis[4,8,11-tris[(4-methylphenyl)sulfonyl]-1,4,8,11-tetraazacyclotetradecane;1,1'-(1,4-(phenylenedimethylene))-di-(4,8,11-triTosyl)-1,4,8,11-tet-raazacyclotetradecane
• CAS NO: 110078-47-2
• Molecular Formula: C70H90N8O12S6
• Molecular Weight: 1428
• EINECS: -0
• Mol File: 110078-47-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.282±0.06 g/cm3 (20 ºC 760 Torr)
• CAS DataBase Reference: 1,4,8,11-Tetraazacyclotetradecane, 1,1'-[1,4-phenylenebis(Methylene)]bis[4,8,11-tris[(4-Methylphenyl)sulfon yl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4,8,11-Tetraazacyclotetradecane, 1,1'-[1,4-phenylenebis(Methylene)]bis[4,8,11-tris[(4-Methylphenyl)sulfon yl]-(110078-47-2)
• EPA Substance Registry System: 1,4,8,11-Tetraazacyclotetradecane, 1,1'-[1,4-phenylenebis(Methylene)]bis[4,8,11-tris[(4-Methylphenyl)sulfon yl]-(110078-47-2)

Safety Data

• Hazardous Substances Data: 110078-47-2(Hazardous Substances Data)

Usage

General Description

1,4,8,11-Tetraazacyclotetradecane, 1,1'-[1,4-phenylenebis(Methylene)]bis[4,8,11-tris[(4-Methylphenyl)sulfon yl]- is a complex chemical compound consisting of a cyclic tetraamine and a bisulfonated aromatic moiety. It is an organic compound commonly used as a ligand in coordination chemistry and as a chelating agent in metal ion coordination. Its structure and properties make it suitable for a variety of applications, including catalysis, chemical analysis, and medical imaging. The compound’s unique structure and versatility have led to its widespread use in various fields of chemistry and materials science.

Upstream product

• 6315-52-2 1,2-bis-tosyloxyethane 
• 98-59-9 p-toluenesulfonyl chloride 
• 623-24-5 1,4-bis(bromomethyl)benzene 
• 104395-69-9 tris-(p-toluenesulfonyl)-1,4,8,11-tetraazacyclotetradecane 

Relevant articles and documents

IMPROVED AND COMMERCIALLY VIABLE PROCESS FOR THE PREPARATION OF HIGH PURE PLERIXAFOR BASE

The present invention relates to an improved and commercially viable process for the preparation of ≥ 99.8% pure plerixafor base (1) by HPLC. The process of the present invention involves simple crystallization techniques to isolate the compounds at each step without employing the laborious column chromatography technique. The solid state characteristics of plerixafor base also discussed by PXRD, DSC and I.R spectroscopy.

Synthesis and structure-activity relationships of phenylenebis(methylene)- linked bis-tetraazamacrocycles that inhibit HIV replication. Effects of macrocyclic ring size and substituents on the aromatic linker

We have previously described the potent and selective inhibition of several strains of human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) by JM2763, an n-propyl-linked dimer of the 1,4,8,11- tetraazamacrocyclic(cyclam) ring system. Upon further investigation, we have also found that incorporating an aromatic rather than aliphatic linker leads to analogs with higher antiviral potency. The prototype, JM3100 (19a, isolated as the octahydrochloride salt), which contains a p- phenylenebis(methylene) moiety linking the cyclam rings, inhibited the replication of HIV-1 (III(B)) and HIV-2 (ROD) at EC50's of 4.2 and 5.9 nM, respectively, while remaining nontoxic to MT-4 cells at concentrations exceeding 421 μM. In order to identify the structural features of bis- tetraazamacrocycles required for potent activity, we have prepared a novel series of phenylenebis(methylene)-linked analogs, in which the macrocyclic ring size was varied from 12 to 16 ring members. Depending upon the substitution of the phenylenebis-(methylene) linker (para or meta), sub- micromolar anti-HIV activity was exhibited by analogs bearing macrocycles of 12-14 ring members but with varying cytotoxicity to MT-4 cells. Furthermore, while we found that identical macrocyclic rings are not required for activity, substituting an acyclic polyamine equivalent for one of the cyclam rings in 19a resulted in a substantial reduction in anti-HIV potency, clearly establishing the importance of the constrained macrocyclic structure. A short series of transition metal complexes of 19a were also prepared and evaluated. Complexes of low kinetic stability such as the bis-zinc complex retained activity comparable to that of the parent compound. Finally, the activity of bicyclam analogs appears to be insensitive to the electron-withdrawing or - donating properties of substituents introduced onto the linker, but sterically hindering groups such as phenyl markedly reduced activity. As a result, several analogs with anti-HIV potency comparable to that of 19a have been identified.