110085-65-9

Upstream product

• 142682-84-6 1-((3aR,4R,6R,6aR)-6-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-6-phenylpyrimidine-2,4(1H,3H)-dione 
• 105967-11-1 6-iodo-uridine 
• 98-80-6 phenylboronic acid 
• 142682-82-4 5'-O-(terrt-butyldimethylsilyl)-2',3'-O-isopropylidene-6-iodouridine 
• 102147-76-2 5'-O-(t-butyldimethylsilyl)-2',3'-O-isopropylideneuridine 

Relevant academic research and scientific papers

Synthesis of 6-aryluridines via Suzuki-Miyaura cross-coupling reaction at room temperature under aerobic ligand-free conditions in neat water

A new and efficient ligandless cross-coupling reaction of 6-iodouridine with various boronic acids in the presence of Na2PdCl4 was performed at room temperature in aerobic water. The target 6-aryl analogues were obtained in moderate to good yields depending on the boronic acid nature.

Practical synthesis of 6-aryluridines via palladium(II) acetate catalyzed Suzuki-Miyaura cross-coupling reaction

Sugar-protected 6-halouridine derivatives underwent Suzuki-Miyaura cross-coupling reactions with arylboronic acids in the presence of palladium(II) acetate as a catalyst, triphenylphosphine as a ligand, and sodium carbonate as a base. This methodology is

Synthesis of C-6-substituted uridine phosphonates through aerobic ligand-free Suzuki-Miyaura cross-coupling

An efficient protocol for the construction of C-6-(hetero)aryl-substituted uridine phosphonate analogues utilizing an aerobic, ligand-free Suzuki-Miyaura cross-coupling reaction of a 6-iodo-precursor in aqueous media has been established. The method presents a modular approach toward the target compounds as demonstrated by the synthesis of a small library comprising 14 novel nucleoside phosphonates.