110098-07-2

Basic information

• Product Name: 5-acetyl-1-β-D-arabinofuranosylcytosine
• CAS NO: 110098-07-2
• Molecular Weight: 285.257
• Mol File: 110098-07-2.mol

Chemical Properties

• CAS DataBase Reference: 5-acetyl-1-β-D-arabinofuranosylcytosine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-acetyl-1-β-D-arabinofuranosylcytosine(110098-07-2)
• EPA Substance Registry System: 5-acetyl-1-β-D-arabinofuranosylcytosine(110098-07-2)

Safety Data

• Hazardous Substances Data: 110098-07-2(Hazardous Substances Data)

Upstream product

• 110098-06-1 1-(2,3,5-tri-O-acetyl-β-D-arabinofuranosyl)-5-<2-(trimethylsilyl)ethynyl>cytosine 

Relevant articles and documents

Acetylenic nucleosides. 4. 1-β-D-arabinofuranosyl-5-ethynylcytosine. Improved synthesis and evaluation of biochemical and antiviral properties

5-Ethynyl-1-β-D-arabinofuranosylcytosine (EAC) was prepared from 1-(2,3,5-tri-O-acetyl-β-D-arabinofuranosyl)cytosine by iodination followed by coupling with (trimethylsilyl)acetylene and deblocking. At 50 μM, EAC was found to inhibit the in vitro replication of herpes simplex virus type 1 and type 2 by >99%. EAC also showed activity against a strain of HSV-1 resistant to (E)-5-(2-bromovinyl)-2'-deoxyuridine which has an alteration of the virus-induced thymidine kinase (TK).. At 100 μM, EAC did not inhibit the in vitro growth of leukemia L1210 and HeLa cells. EAC was resistant to the action of dCR-CR deaminase, its rate of deamination being approximately 2% that of dCR. The compound was a poor substitute for dCR kinase, but it was phosphorylated by HSV-1- and HSV-2-induced TKs at 50% and 30%, respectively, the rate of thymidine.