110101-66-1 Usage
Uses
Used in Pharmaceutical Industry:
Tirilazad mesylate is used as a neuroprotective agent for its potential to mitigate the effects of oxidative stress and inflammation in the brain, particularly in conditions like stroke and traumatic brain injury. It is believed to improve neurological outcomes by inhibiting lipid peroxidation and scavenging free radicals, thus protecting brain cells from damage.
Despite the promising preclinical data, clinical trials have shown mixed results, indicating the need for further research to fully understand the therapeutic applications of tirilazad mesylate in human patients.
Check Digit Verification of cas no
The CAS Registry Mumber 110101-66-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,0,1,0 and 1 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 110101-66:
(8*1)+(7*1)+(6*0)+(5*1)+(4*0)+(3*1)+(2*6)+(1*6)=41
41 % 10 = 1
So 110101-66-1 is a valid CAS Registry Number.
InChI:InChI=1/C38H52N6O2/c1-26-22-31-29-9-8-27-23-28(45)10-12-37(27,2)30(29)11-13-38(31,3)35(26)32(46)25-41-18-20-43(21-19-41)34-24-33(42-14-4-5-15-42)39-36(40-34)44-16-6-7-17-44/h10-12,23-24,26,29,31,35H,4-9,13-22,25H2,1-3H3/t26-,29-,31+,35-,37+,38+/m1/s1
110101-66-1Relevant academic research and scientific papers
Novel 21-Aminosteroids That Inhibit Iron-Dependent Lipid Peroxidation and Protect against Central Nervous System Trauma
Jacobsen, E. Jon,McCall, John M.,Ayer, Donald E.,VanDoornik, Fred J.,Palmer, John R.,et al.
, p. 1145 - 1151 (2007/10/02)
A novel class of 21-aminosteroids has been developed.Compounds within this series are potent inhibitors of iron-dependent lipid peroxidation in rat brain homogenates with IC50's as low as 3 μM.Furthermore, selected members enhance early neurolo
