1101119-45-2

Upstream product

• 859855-53-1 3-amino-4-fluorobenzonitrile 
• 1101120-05-1 3-formylpyrazolo[1,5-a]pyridine-5-carbonitrile 
• 1101120-80-2 5-cyano-2-fluorobenzene-1-sulfonyl chloride 
• 302-15-8 methylhydrazine sulfuric acid 

Downstream Products

• 1101119-53-2 5-cyano-N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-N-methyl-2-(2-morpholinoethoxy)benzenesulfonohydrazide hydrochloride 
• 1101119-49-6 5-cyano-N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-2-((2-(dimethylamino)ethyl)(methyl)amino)-N-methylbenzenesulfonohydrazide hydrochloride 

Relevant academic research and scientific papers

Novel pyrazolo[1,5-a]pyridines with improved aqueous solubility as p110α-selective PI3 kinase inhibitors

As part of our investigation into pyrazolo[1,5-a]pyridines as novel p110α selective PI3 kinase inhibitors, we report a range of analogues with improved aqueous solubility by the addition of a basic amine. The compounds demonstrated comparable p110α potency and selectivity to earlier compounds but with up to 1000× greater aqueous solubility, as the hydrochloride salts. The compounds also displayed good activity in a cellular assay of PI3 kinase activity.

PYRAZOLO[1,5-A]PYRIDINES AND THEIR USE IN CANCER THERAPY

Pyrazolo[1,5-a]pyridines are described, including methods for their preparation, and their use as agents or drugs for cancer therapy, both alone or in combination with radiation and/or other anticancer drugs.