1101133-95-2Relevant academic research and scientific papers
Synthesis of 2α-and 2β-substituted-14-epi-previtamin D 3 and their genomic activity
Sawada, Daisuke,Katayama, Tomoyuki,Tsukuda, Yuya,Saito, Nozomi,Saito, Hiroshi,Takagi, Ken-Ichiro,Ochiai, Eiji,Ishizuka, Seiichi,Takenouchi, Kazuya,Kittaka, Atsushi
experimental part, p. 5407 - 5423 (2010/08/19)
2α-and 2α-Substituted analogs of 14-epi-previtamin D3 were synthesized and isolated after thermal isomerization of 14-epi-vitamin D3 triene at 80 °C.The VDR binding affinity and transactivation activity of osteocalcin promoter in HOS cells were tested, and the 2a-methyl-substituted analog was found to have greater genomic activity than 14-epi-previtamin D 3.We found that modification at the C2 position of the seco-steroidal skeleton afforded interesting effects for biological genomic activity for the pre-vitamin D form as well as the natural vitamin D form.
