1101136-35-9

Upstream product

• 1369796-49-5 methyl 2-hydroxy-8-phenyloctanoate 
• 1369796-48-4 methyl 2-hydroxy-8-phenyloctanimidate 
• 1101136-32-6 2-hydroxy-8-phenyloctanenitrile 
• 121784-15-4 7-phenylheptanal 
• 3208-25-1 7-phenylheptan-1-ol 

Downstream Products

• 1101136-39-3 tert-butyl 3-(2-hydroxy-8-phenyloctanamido)propanoate 
• 1101136-37-1 methyl 2-(2-hydroxy-8-phenyloctanamido)acetate 
• 1369796-83-7 2-hydroxy-8-phenyl-N-((5-(4-(pyridin-4-ylmethoxy)phenyl)-1,3,4-thiadiazol-2-yl)methyl)octanamide 
• 1369794-89-7 2-oxo-8-phenyl-N-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)octanamide 
• 1369796-10-0 2-oxo-8-phenyl-N-((5-(4-(pyridin-4-ylmethoxy)phenyl)-1,3,4-thiadiazol-2-yl)methyl)octanamide 
• 1369796-50-8 2-hydroxy-8-phenyl-N-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)octanamide 
• 1369796-82-6 2-hydroxy-N-((5-(4-hydroxyphenyl)-1,3,4-thiadiazol-2-yl)methyl)-8-phenyloctanamide 
• 1369796-58-6 N-((5-(4-((3-fluorobenzyl)oxy)phenyl)-1,3,4-thiadiazol-2-yl)methyl)-2-hydroxy-8-phenyloctanamide 
• 1369796-01-9 N-((5-(4-((3-fluorobenzyl)oxy)phenyl)-1,3,4-thiadiazol-2-yl)methyl)-2-oxo-8-phenyloctanamide 

Relevant academic research and scientific papers

ALPHA-KETOAMIDE DERIVATIVES USEFUL ENDOTHELIAL LIPASE INHIBITORS

The present invention is directed to α-ketoamide derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by endothelial lipase, for example, cardiovascular disorders.

Structure-activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A2 enzymes

A variety of 2-oxoamides and related amides based on natural and non-natural amino acids were synthesized. Their activity on two human intracellular phospholipases (GIVA cPLA2 and GVIA iPLA2) and one human secretory phospholipase (GV