110144-36-0

Basic information

• Product Name: methyl 7-bromo-8-hydroxy-2-(2'-aminophenyl)quinoline-5'-carboxylate
• Synonyms: methyl 7-bromo-8-hydroxy-2-(2'-aminophenyl)quinoline-5'-carboxylate
• CAS NO: 110144-36-0
• Molecular Weight: 373.206
• Mol File: 110144-36-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 7-bromo-8-hydroxy-2-(2'-aminophenyl)quinoline-5'-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 7-bromo-8-hydroxy-2-(2'-aminophenyl)quinoline-5'-carboxylate(110144-36-0)
• EPA Substance Registry System: methyl 7-bromo-8-hydroxy-2-(2'-aminophenyl)quinoline-5'-carboxylate(110144-36-0)

Safety Data

• Hazardous Substances Data: 110144-36-0(Hazardous Substances Data)

Upstream product

• 111714-47-7 3-acetyl-4-aminobenzoic acid methyl ester 
• 99573-20-3 2-Amino-3-(benzyloxy)-4-bromobenzaldehyde 
• 110144-35-9 methyl 8-(benzyloxy)-7-bromo-2-(2'-aminophenyl)quinoline-5'-carboxylate 

Relevant articles and documents

Streptonigrin and Lavendamycin Partial Structures. Probes for the Minimum, Potent Pharmacophore of Streptonigrin, Lavendamycin, and Synthetic Quinoline-5,8-diones

The preparation and evaluation of 7-amino-4,8-dioxo-2-(2'-pyridyl)quinoline-6'-carboxylic acid (5a) and 7-amino-2-(2'-aminophenyl)-5,8-dioxoquinoline-5'-carboxylic acid (6a) constituting potential minimum, potent pharmacophores of streptonigrin (1a) and lavendamycin (2a), two structurally related naturally occurring antitumor antibiotics, are detailed.In contrast to observations associated with streptonigrin and lavendamycin in which the C-ring C-6' carboxylic acid potentiates the antitumor, antimicrobial, and cytotoxic properties of the naturally occurring, substituted 7-aminoquinoline-5,8-dione AB ring systems, the C-6'/C-5' carboxylic acid of 5a/6a diminishes the observed antimicrobial and cytotoxic properties of the 2-(2'-pyridyl)- and 2-(2'-aminophenyl)-7-aminoquinoline-5,8-diones.A direct comparison of the antimicrobial and cytotoxic properties of a complete set of stereptonigrin and lavendamycin partial structures is detailed in efforts to define the role peripheral substituents play in potentiating the biological properties of the naturally occurring and synthetic agents bearing the 7-aminoquinoline-5,8-dione AB ring system and in efforts to define the minimum, potent pharmacohore of the naturally occurring antitumor antibiotics.The relationship of these observations to a chemical mechanism of cellular toxicity is discussed.