110166-75-1Relevant academic research and scientific papers
Oxypalladation Initiating the Oxid-ative Heck Reaction with Alkenyl -Alcohols: Synthesis of Isocoumarin–Alkanones
Zheng, Meifang,Huang, Liangbin,Tong, Qizhen,Wu, Wanqing,Jiang, Huanfeng
supporting information, p. 663 - 667 (2017/01/18)
Highly regioselective nucleopalladation for the oxidative coupling of internal alkynes with alkenyl alcohols by using green and low-costing oxygen as the sole oxidant was investigated. This one-pot cascade cyclization proceeds through Pd-catalyzed intramolecular C–O bond cyclization, insertion of nonbiased alkenyl alcohols, β-H elimination, and reinsertion of a HPdX species, which is finally transferred to the target ketones. This method has the advantages of mild conditions, good functional group tolerance, and can be performed with unactivated alkenes to afford isocoumarin derivatives.
Gold-catalyzed transesterification of ortho-alkynylbenzoic acid esters: a novel protecting group for alcohols and phenols
Umetsu, Kazuteru,Asao, Naoki
body text, p. 7046 - 7049 (2009/04/07)
Treatment of ortho-alkynylbenzoic acid esters with excess amounts of EtOH in the presence of a gold catalyst results in the liberation of alcohols or phenols in high yields under mild conditions. The protection of alcohols and phenols proceeds smoothly by use of ortho-alkynylbenzoic acid or ortho-iodobenzoyl chloride. Highly chemoselective deprotections are described.
