1101668-39-6

Basic information

• Product Name: Proparyl-PEG5-methane
• Synonyms: Proparyl-PEG5-methane;2,5,8,11,14-Pentaoxaheptadec-16-yne;mPEG4-Alkyne;Propargyl-PEG5-methane;mPEG4-Propyne
• CAS NO: 1101668-39-6
• Molecular Formula: C₁₂H₂₂O₅
• Molecular Weight: 246.30008
• Mol File: 1101668-39-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 304.2±32.0 °C(Predicted)
• Appearance: /
• Density: 1.016±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Proparyl-PEG5-methane(CAS DataBase Reference)
• NIST Chemistry Reference: Proparyl-PEG5-methane(1101668-39-6)
• EPA Substance Registry System: Proparyl-PEG5-methane(1101668-39-6)

Safety Data

• Hazardous Substances Data: 1101668-39-6(Hazardous Substances Data)

Usage

Description

Propargyl-PEG5-methane has a propargyl group which can react with azide compounds via copper catalyzed Click Chemistry reactions. The PEG units increase water-solubility of the molecule.

Upstream product

• 23783-42-8 tetraethylene glycol monomethyl ether 
• 624-65-7 2-propynyl chloride 
• 106-96-7 propargyl bromide 

Downstream Products

• 1449418-28-3 1-(2-(4-(2,5,8,11,14-pentaoxapentadecyl)-1H-1,2,3-triazol-1-yl)-1-phenylethoxy)-2,2,6,6-tetramethylpiperidine 

Relevant articles and documents

Rapid preparation of multifunctional surfaces for orthogonal ligation by microcontact chemistry

Microcontact chemistry has been applied to patterned glass and silicon substrates by successive reaction of unprotected and monoprotected heterobifunctional linkers with alkene-terminated self-assembled monolayers (SAMs) to produce bi-, tri-, and tetrafunctional surfaces. Photochemical microcontact printing of an azide thiol linker followed by immobilization of an acid thiol linker on an undecenyl-terminated SAM results in a well-defined, micropatterned surface with terminal azide, acid, and alkene groups. Biologically relevant molecules (biotin, carbohydrates) have been selectively attached to the surface by means of orthogonal ligation chemistry, and the resulting microarrays display selective binding to fluorescently labeled proteins. An orthogonally addressable, tetrafunctional surface (azide, acid, alkene, and amine) can be prepared by an additional printing step of a tert-butyloxycarbonyl (Boc)-protected alkyne amine linker on the azide structures by using the copper(I)-catalyzed azide-alkyne Huisgen cycloaddition and subsequent removal of the protective group. Copyright

Polyethylene glycol-based homologated ligands for nicotinic acetylcholine receptors

A homologous series of polyethylene glycol (PEG) monomethyl ethers were conjugated with three ligand series for nicotinic acetylcholine receptors. Conjugates of acetylaminocholine, the cyclic analog 1-acetyl-4,4-dimethylpiperazinium, and pyridyl ether A-84543 were prepared. Each series was found to retain significant affinity at nicotinic receptors in rat cerebral cortex with tethers of up to six PEG units. Such compounds are hydrophilic ligands which may serve as models for fluorescent/affinity probes and multivalent ligands for nAChR.