1101848-95-6

Basic information

• Product Name: (S)-(+)-1-(4-fluorophenyl)-1-(3-methylaminopropyl)-1,3-dihydroisobenzofuran-5-carbonitrile, (-)-di-p-toluoyl-D-tartaric acid salt
• Synonyms: (S)-(+)-1-(4-fluorophenyl)-1-(3-methylaminopropyl)-1,3-dihydroisobenzofuran-5-carbonitrile, (-)-di-p-toluoyl-D-tartaric acid salt
• CAS NO: 1101848-95-6
• Molecular Weight: 696.729
• Mol File: 1101848-95-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-(+)-1-(4-fluorophenyl)-1-(3-methylaminopropyl)-1,3-dihydroisobenzofuran-5-carbonitrile, (-)-di-p-toluoyl-D-tartaric acid salt(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(+)-1-(4-fluorophenyl)-1-(3-methylaminopropyl)-1,3-dihydroisobenzofuran-5-carbonitrile, (-)-di-p-toluoyl-D-tartaric acid salt(1101848-95-6)
• EPA Substance Registry System: (S)-(+)-1-(4-fluorophenyl)-1-(3-methylaminopropyl)-1,3-dihydroisobenzofuran-5-carbonitrile, (-)-di-p-toluoyl-D-tartaric acid salt(1101848-95-6)

Safety Data

• Hazardous Substances Data: 1101848-95-6(Hazardous Substances Data)

Upstream product

• 62498-67-3 rac-desmethylcitalopram 
• 32634-68-7 (2S,3S)-di-4-toluoyltartaric acid 

Downstream Products

• 144025-14-9 (+)-Desmethylcitalopram 

Relevant articles and documents

Process for the preparation of escitalopram

The present invention relates to a novel process for the preparation of Escitalopram, which comprises: (ii) de-methylating (±)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile (Formula II) (Citalopram) to produce (±)-1-[3-(methylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile (desmethyl Citalopram) (XII), (iii) isolating the pure desmethyl Citalopram (XII), (iv) separating the enantiomers from the pure desmethyl Citalopram (XII) with an optically active acid to obtain (S)-(+)-1-[3-(methylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile ((S)-(+)-desmethyl Citalopram) (XIII), (v) methylating an enantiomerically pure compound (XIII) using suitable methylating agent to produce Escitalopram (I).