1101869-71-9Relevant academic research and scientific papers
Two new pyrrolidine alkaloids, codonopsinol C and codonopiloside A, isolated from codonopsis pilosula
Wakana, Daigo,Kawahara, Nobuo,Goda, Yukihiro
, p. 1315 - 1317 (2014/01/06)
A new pyrrolidine alkaloid codonopsinol C (1), and pyrrolidine alkaloidal glycoside, codonopiloside A (2), were isolated from the roots of Codonopsis pilosula, along with four known pyrrolidine alkaloids, codonopsinol A (3), codonopsinol B (4), codonopyrrolidium B (5), and radicamine A (6). The structures of the new compounds were established by acid hydrolysis and spectroscopic methods. We describe those structures in this paper.
Synthesis and biological evaluation of a 2-aryl polyhydroxylated pyrrolidine alkaloid-based library
Tsou, En-Lun,Chen, Sih-Yu,Yang, Ming-Hsun,Wang, Shih-Chi,Cheng, Ting-Ren Rachel,Cheng, Wei-Chieh
experimental part, p. 10198 - 10204 (2009/04/07)
Inspired by polyhydroxylated pyrrolidine alkaloid natural products, a 18-membered library of 2-aryl polyhydroxylated pyrrolidines has been efficiently prepared in two or three synthetic steps from the known chiral cyclic nitrones with high yield and purity and excellent stereoselectivity. The inhibitory activity of all these compounds against various glycosidase enzymes was evaluated. Interestingly, 15 and 19 show better inhibitory activities than radicamine A (20) and B (18) against α-glucosidases. The IC50 values of 15 and 19 are 1.1 and 0.5 μM, respectively. In this study, we also discovered the substituent(s) on the aryl ring could affect the inhibition potency and selectivity against glycosidases.
