110187-44-5Relevant academic research and scientific papers
Bioreduction of β-carboline imines to amines employing Saccharomyces bayanus
Espinoza-Moraga, Marlene,Petta, Tania,Vasquez-Vasquez, Marco,Laurie, V. Felipe,Moraes, Luis A.B.,Santos, Leonardo Silva
body text, p. 1988 - 1992 (2010/11/05)
β-Carboline imine reductions mediated by Saccharomyces bayanus have been described achieving moderate to good enantiomeric excesses of the amine products. The enantiomeric excesses of the bioreduction showed a dependence on the imine substituents. Compoun
Mild Oxidation of 1,2,3,4-Tetrahydro-β-carbolines
Mokrosz, M.J.,Paluchowska, M.H.,Misztal, S.
, p. 264 - 268 (2007/10/02)
Oxidation of 1-(aryl or heteroaryl)-1,2,3,4-tetrahydro-β-carbolines (1a-r) with KMnO4 in dry THF afforded in the most cases almost exclusively 3,4-dihydro products (2) with a yield of 28-94percent.Only in few cases (1c, 1i, 1m) the reaction was non-selective and a significant amount of the fully aromatized products (3) (30-40percent of the reaction mixture) was observed.The influence of both the substituent nature and the substitution modes on the observed yield and selectivity of the reaction was discussed.Key words: 1,2,3,4-tetrahydro-β-carbolines, 3,4-dihydro-β-carbolines, selective oxidation, oxidation with KMnO4 in cold THF, substituent effect
