1101871-08-2Relevant academic research and scientific papers
Enantioselective total synthesis of (+)-cassiol
Petrova, Krastina V.,Mohr, Justin T.,Stoltz, Brian M.
supporting information; experimental part, p. 293 - 295 (2009/08/08)
(Chemical Equation Presented) An enantioselective total synthesis of (+)-cassiol is reported. The complex derived from Pd2(pmdba) 3 and enantiopure t-BuPHOX ligand catalyzes enantioconvergent decarboxylative alkylation to generate the quaternary carbon stereocenter at an early stage. The overall synthetic strategy involves a convergent late-stage coupling of two fragments. The synthesis features a longest linear sequence of eight steps.
