110190-08-4Relevant articles and documents
Sequential Difunctionalization of 2-Iodobiphenyls by Exploiting the Reactivities of a Palladacycle and an Acyclic Arylpalladium Species
Chen, Dushen,Shi, Guangfa,Jiang, Hang,Zhang, Yu,Zhang, Yanghui
, p. 2130 - 2133 (2016)
A novel sequential difunctionalization reaction of 2-iodobiphenyl has been developed by exploiting the distinct reactivities of a palladacycle and an acyclic arylpalladium species. In this tandem reaction, an in situ formed dibenzopalladacyclopentadiene reacts selectively with an alkyl halide, after which the thus formed acyclic arylpalladium species selectively undergoes a Heck reaction with an alkene. This work demonstrates the strong relationship between the coordination mode of a transition metal complex and its reactivity, which could shed light on the mechanisms of other transition-metal-catalyzed reactions and offer the opportunity to develop other synthetically enabling organic transformations.
Rapid Iododeboronation with and without Gold Catalysis: Application to Radiolabelling of Arenes
Webster, Stacey,O'Rourke, Kerry M.,Fletcher, Conor,Pimlott, Sally L.,Sutherland, Andrew,Lee, Ai-Lan
, p. 937 - 943 (2018)
Radiopharmaceuticals that incorporate radioactive iodine in combination with single-photon emission computed tomography imaging play a key role in nuclear medicine, with applications in drug development and disease diagnosis. Despite this importance, there are relatively few general methods for the incorporation of radioiodine into small molecules. This work reports a rapid air- and moisture-stable ipso-iododeboronation procedure that uses NIS in the non-toxic, green solvent dimethyl carbonate. The fast reaction and mild conditions of the gold-catalysed method led to the development of a highly efficient process for the radiolabelling of arenes, which constitutes the first example of an application of homogenous gold catalysis to selective radiosynthesis. This was exemplified by the efficient synthesis of radiolabelled meta-[125I]iodobenzylguanidine, a radiopharmaceutical that is used for the imaging and therapy of human norepinephrine transporter-expressing tumours.
A phase-dependent photoluminescent discotic liquid crystal bearing a graphdiyne substructure
Yu, Zhen,Chen, Xu-Man,Liu, Zhi-Yang,Wang, Meng,Huang, Shuai,Yang, Hong
, p. 911 - 914 (2021)
In recent years, graphdiyne and its derivatives with fascinating electro-optic properties have attracted tremendous scientific attention. Here we design and synthesize a graphdiyne-derived discotic liquid crystal material by decorating six wedge-shaped 3,
A method for preparing isothiaurea compounds based on substituted iodobenzene
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Paragraph 0017, (2021/12/07)
The present invention discloses a method for preparing isothiaurea compounds based on substituted iodobenzene, thiourea and substituted iodobenzene as a substrate, in the presence of metal hydrides, react in a solvent, and prepare isothiurea compounds. Is