1102-96-1Relevant academic research and scientific papers
Synthesis of Hoodigogenin A, aglycone of natural appetite suppressant glycosteroids extracted from Hoodia gordonii
Geoffroy, Philippe,Ressault, Blandine,Marchioni, Eric,Miesch, Michel
, p. 702 - 708 (2011)
14β-hydroxy pregnane glycosides extracted from Hoodia gordonii, a succulent plant isolated from Apocynaceae are suggested to have appetite suppressant properties in animals and humans. However, limited reports on biological studies concerning the appetite suppressant properties are available in the open literature. One reason for that is the poor availability of these glycosteroids because H. gordonii is a protected plant and the yield of extraction lies between 0.003% and 0.02%. Starting from 3α,12α- diacetoxy-pregnanone 1, we disclose in this report the synthesis of Hoodigogenin A, the aglycone of the natural 14β-hydroxy pregnane glycosides extracted from H. Gordonii.
Norrish-Prins reaction as a key step in the synthesis of 14β-hydroxy-5α (or 5β or Δ5,6)-pregnane derivatives
Geoffroy, Philippe,Ressault, Blandine,Marchioni, Eric,Miesch, Michel
supporting information; experimental part, p. 1166 - 1175 (2011/08/22)
Numerous bioactive glycosteroids are characterized by aglycones bearing a 14β-hydroxy pregnane skeleton like boucerin and isoramanone. In general, the syntheses of the latter are achieved by acidic hydrolysis of the corresponding glycosteroids. These agly
