110203-93-5Relevant academic research and scientific papers
Biomimetic oxidation of clemastine fumarate
Froehlich,Pietzyk,Smolinka,Goeber
, p. 409 - 414 (2007/10/03)
The reaction of clemastine fumarate (1) with the biomimetic system manganese(III)-5,10,15,20-tetrakis(pentafluorophenyl)porphyrin chloride (MnTPFPPCl)/imidazole/hydrogen peroxide in a mixture of dichlormethane/methanol affords several metabolites. These compounds are products of O-dealkylation, N-demethylation, N-oxidation and separation of water. The reaction of 1 in aqueous solution with manganese(III)-5,10,15,20-tetrakis(pentafluorophenyl)-β-tetrasulfonat oporphyrin chloride (MnTPFPS4PCl) as catalyst additional generates products of aromatic hydroxylation. Products were identified by TLC, UV, and MS. Thereby we found a close conformity with rat metabolism.
