110206-17-2Relevant academic research and scientific papers
Synthesis and biological action of the aminotetrahydroisoquinocarbazoles and related compounds: A new class of compounds with antiarrhythmic activity
Shimoji,Tomita,Hashimoto,Saito,Morisawa,Mizuno,Yorikane,Koike
, p. 816 - 822 (2007/10/02)
A series of 12-aminotetrahydroisoquinocarbazoles and related compounds were synthesized using an intramolecular Diels-Alder reaction and screened for antiarrhythmic activity in chloroform-induced ventricular arrhythmias in mice. Several compounds showed m
Intramolecular Diels-Alder Reactions of Indole-3-acrylates
Eberle, Marcel K.,Shapiro, Michael J.,Stucki, Roland
, p. 4661 - 4665 (2007/10/02)
Indole-3-carboxaldehyde was alkylated to give the N-alkylated indole-3-carboxaldehydes 1a-d and 4.These ware extended by two carbon atoms with methyl (triphenylphosphoranylidene)acetate to the methyl indole-3-acrylates 2a-d and 5.When these indoles were heated to 300 deg C the (tetrahydro)carbazoles 3a-d and 6a were obtained.Compound 3c represents a novel ring system.Indole-3-carboxaldehyde was also acylated to give the N-acylated indole-3-carboxaldehydes 1e,f.These were carbon extended to the N-acylated indole-3-acrylates 2e,f which upon heating to 300 deg C gave the (tetrahydro)carbazoles 3e,f and 6b.
