110217-09-9Relevant academic research and scientific papers
SYNTHESIS OF 11-COREY'S 11-DEOXYALDEHYDE - A PROSTAGLANDIN SYNTHON - FROM 1,5-CYCLOOCTADIENE
Dyadchenko, M. A.,Danilova, G. A.,Spanig, I.,Schick, G.,Pivnitskii, K. K.
, p. 2198 - 2202 (2007/10/02)
A new scheme was developed for the synthesis of 6-formyl-cis-2-oxabicyclooctan-3-ones epimeric with respect to the aldehyde group, which are prostaglandin synthons and 11-deoxy analogs of Corey's aldehyde previously used in prostanoid synthesis.The starting material was 1,5-cyclooctadiene, which gives the synthons with an overall yield of up to 24percent in five or eight stages in the two versions of the scheme.
