110230-98-3 Usage
Uses
Used in Photodynamic Therapy:
Talaporfin sodium is used as a photosensitizer in photodynamic therapy (PDT) for the treatment of various types of cancer. It has been approved in Japan for the treatment of early-stage lung cancer and is being developed for other hyperproliferative diseases, such as liver metastases arising from colorectal cancer, wet age-related macular degeneration, and atherosclerosis.
Used in Cancer Treatment:
In the clinical study of patients with early lung cancer, talaporfin sodium demonstrated a complete response in approximately 86% of the lesions when administered at 40 mg/m2 followed by laser irradiation at 100 J/cm2, 4-6 hours later. The activated photosensitizer reacts with endogenous oxygen to generate singlet oxygen, leading to apoptosis and vascular ischemia of the targeted tissue.
Used in Light-Emitting Diode (LED) Activation:
A clinical study involving a variety of refractory solid tumors demonstrated that intratumoral delivery of light-emitting diodes was effective when used with talaporfin sodium, resulting in a 33% overall response rate with no cutaneous phototoxicity.
Brand Name: Laserphyrin
Originator
Nippon Petrochem. (Japan)
Check Digit Verification of cas no
The CAS Registry Mumber 110230-98-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,0,2,3 and 0 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 110230-98:
(8*1)+(7*1)+(6*0)+(5*2)+(4*3)+(3*0)+(2*9)+(1*8)=63
63 % 10 = 3
So 110230-98-3 is a valid CAS Registry Number.
InChI:InChI=1/C38H41N5O9/c1-7-20-16(3)24-12-26-18(5)22(9-10-32(45)46)35(42-26)23(11-31(44)41-30(37(49)50)15-33(47)48)36-34(38(51)52)19(6)27(43-36)14-29-21(8-2)17(4)25(40-29)13-28(20)39-24/h7,12-14,18,22,30,39-40H,1,8-11,15H2,2-6H3,(H,41,44)(H,45,46)(H,47,48)(H,49,50)(H,51,52)/b24-12-,25-13-,26-12-,27-14-,28-13-,29-14-,35-23-,36-23-/t18-,22-,30-/m0/s1
