110258-96-3

Basic information

• Product Name: 13-acetyl-10-deacetyl baccatin III
• Synonyms: 13-acetyl-10-deacetyl baccatin III
• CAS NO: 110258-96-3
• Molecular Weight: 586.636
• Mol File: 110258-96-3.mol

Chemical Properties

• CAS DataBase Reference: 13-acetyl-10-deacetyl baccatin III(CAS DataBase Reference)
• NIST Chemistry Reference: 13-acetyl-10-deacetyl baccatin III(110258-96-3)
• EPA Substance Registry System: 13-acetyl-10-deacetyl baccatin III(110258-96-3)

Safety Data

• Hazardous Substances Data: 110258-96-3(Hazardous Substances Data)

Usage

Source

Derived from the Pacific yew tree (Taxus brevifolia)

Purpose

Precursor for the production of the anti-cancer drug paclitaxel (Taxol)

Advantage

More easily accessible and cost-effective alternative for paclitaxel synthesis

Cancer treatment potential

Effective in treating various types of cancer, including breast, ovarian, and lung cancer

Pharmaceutical industry relevance

Key intermediate in paclitaxel synthesis and potential for further development

Upstream product

• 110258-95-2 7,10-di(2,2,2-tricholoroethyloxycarbonyl)-13-acetyl-10-deacetyl baccatin III 
• 95603-44-4 7,10-di-(2,2,2-trichloroethyloxycarbonyl)-10-deacetylbaccatin III 
• 32981-86-5 10-deacetylbaccatin III 

Downstream Products

• 1402820-67-0 13-acetyl-7,10-dimethoxy-10-DAB 
• 709673-79-0 7,10-methylthiomethyl-10-deacetylbaccatin III 
• 1380584-07-5 1-hydroxy-7β,10β-di-methoxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-trethylsilyloxy-3-phenylpropanoate} 
• 183133-94-0 4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene 
• 183133-96-2 carbazitaxel 
• 1402820-66-9 13-acetyl-7,10-methylthiomethyl-10-DAB 

Relevant articles and documents

SOLID STATE FORMS OF CABAZITAXEL AND PROCESSES FOR PREPARATION THEREOF

The invention relates to solid state forms of Cabazitaxel, and processes for preparation, via novel synthetic intermediates, thereof, and formulations comprising one or more of the solid state forms of Cabazitaxel. The present invention further provides pharmaceutical compositions comprising one or more of the solid state forms of Cabazitaxel, and a method of treating hormone-refractory prostate cancer.

CHEMICAL STUDIES OF 10-DEACETYL BACCATIN III. HEMISYNTHESIS OF TAXOL DERIVATIVES.

The chemical reactivities of 10-deacetyl baccatin III and of baccatin III, two natural products extracted from Taxus baccata L., were studied with aim of synthesizing taxol analogues having a modified side-chain at C-13, thereby restoring good binding to tubulin.