11028-71-0 Usage
Chemical Properties
Lyophilized
Uses
Different sources of media describe the Uses of 11028-71-0 differently. You can refer to the following data:
1. Concanavalin A is a unique lectin purified from the jack bean, C. ensiformis, that selectively cross-links cell-surface glycoproteins and affects the initiation of cell agglutination, mitogenesis, and apoptosis. Concanavalin A specifically binds to α-mannose and α-galactose structures found in sugars, glycoproteins, and glycolipids and has been used in affinity chromatography purifications of various glycoproteins and cellular structures. At 20 mg/kg concanavalin A is also used to induce liver injury in experimental mouse models of autoimmune hepatitis in order to study immune regulation by macrophages and T cells. Concanavalin A is toxic to several tumor cell lines and has been reported to induce programmed cell death of cortical neurons by a mechanism similar to that of the amyloid β peptide.
2. As a reagent in analytical and preparative biochemistry; as a probe in studies of cell surface membrane dynamics and cell division.
3. Concanavalin A is a plant lectin that is a T-cell mitogen, and induces apoptosis in human fibroblasts.
Definition
A lectin mitogen that binds specifically to and agglutinates transforms into tumors. It binds to glucose
and mannose residues in the surface.
General Description
Concanavalin A is a protein containing only β-sheets in its structure, and belongs to the legume lectins family.
Hazard
Poison; teratogen; mutagen.
Biochem/physiol Actions
Concanavalin A is known to stimulate acute hepatic inflammation and acts as a T‐cell mitogen. It has inhibitory effect on hepatocellular carcinoma by inducing autophagy.
Check Digit Verification of cas no
The CAS Registry Mumber 11028-71-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,1,0,2 and 8 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 11028-71:
(7*1)+(6*1)+(5*0)+(4*2)+(3*8)+(2*7)+(1*1)=60
60 % 10 = 0
So 11028-71-0 is a valid CAS Registry Number.
