110319-35-2

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 1824-94-8 methyl beta-D-galactopyranoside 

Downstream Products

• 131291-07-1 methyl 3-O-benzoyl-6-O-(tert-butyldiphenylsilyl)-β-D-galactopyranoside 
• 131291-08-2 methyl 2,3-di-O-benzoyl-6-O-(tert-butyldiphenylsilyl)-β-D-galactopyranoside 
• 131291-06-0 methyl 3,4-di-O-benzoyl-6-O-(tert-butyldiphenylsilyl)-β-D-galactopyranoside 
• 110319-39-6 methyl 2,3,4-tri-O-benzoyl-6-O-(tert-butyldiphenylsilyl)-β-D-galactopyranoside 
• 110319-50-1 methyl O-(2,3,4,6-tetra-O-acetyl-α-D-galactopyranosyl)-(1<*>6)-2,3,4-tris-O-(p-phenylbenzoyl)-β-D-galactopyranoside 
• 110319-51-2 methyl O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1<*>6)-2,3,4-tris-O-(p-phenylbenzoyl)-β-D-galactopyranoside 
• 110330-32-0 methyl O-(2,3,4,6-tetra-O-benzoyl-β-D-galactopyranosyl)-(1<*>6)-2,3,4-tris-O-(p-phenylbenzoyl)-β-D-galactopyranoside 
• 110319-53-4 O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1<*>6)-2,3,4-tris-O-(p-phenylbenzoyl)-α-D-galactopyranosyl chloride 
• 110319-49-8 2,3,4-tri-O-(p-phenylbenzoyl)-6-O-(tert-butyldiphenylsilyl)-α-D-galactopyranosyl chloride 
• 110319-44-3 methyl 2,3,4-tris-O-(p-phenylbenzoyl)-β-D-galactopyranoside 
• 110319-47-6 2,3,4-tri-O-acetyl-6-O-(tert-butyldiphenylsilyl)-α-D-galactopyranosyl chloride 
• 110319-48-7 methyl 2,3,4-tri-O-benzoyl-6-O-(tert-butyldiphenylsilyl)-α-D-galactopyranosyl chloride 
• 53182-61-9 methyl 2,3,4-tri-O-benzoyl-β-D-galactopyranoside 
• 121686-51-9 methyl 2-O-benzyl-6-O-(tert-butyldiphenylsilyl)-3,4-O-isopropylidene-β-D-galactopyranoside 

Relevant academic research and scientific papers

Selective Monovalent Galectin-8 Ligands Based on 3-Lactoylgalactoside

Galectin-8 has gained attention as a potential new pharmacological target for the treatment of various diseases, including cancer, inflammation, and disorders associated with bone mass reduction. To that end, new molecular probes are needed in order to better understand its role and its functions. Herein we aimed to improve the affinity and target selectivity of a recently published galectin-8 ligand, 3-O-[1-carboxyethyl]-β-d-galactopyranoside, by introducing modifications at positions 1 and 3 of the galactose. Affinity data measured by fluorescence polarization show that the most potent compound reached a KD of 12 μM. Furthermore, reasonable selectivity versus other galectins was achieved, making the highlighted compound a promising lead for the development of new selective and potent ligands for galectin-8 as molecular probes to examine the protein's role in cell-based and in vivo studies.

BORON CLUSTER-COUPLED COMPOUND

To provide a novel boron-containing compound which increases intratumorous accumulation and tumor retention, and is efficiently taken into a tumor cell.SOLUTION: The present invention relates to a compound represented by formula (I) in the figure or a salt thereof. [In the formula, X represents a divalent to pentavalent organic group; Y represents a linker structure; R represents a monovalent group comprising boron clusters; and n represents 2, 3, 4 or 5.SELECTED DRAWING: None

Synthesis of specifically deoxygenated ligands related to (1->6)-β-D-galacto-oligosaccharides, and studies on their binding to monoclonal antigalactan antibodies

Synthetic deoxygenated derivatives of methyl β-glycosides of (1->6)-β-D-galacto-oligosaccharides were prepared, and their binding to antigalactan monoclonal antibodies X24 and J539 (Fab') was studied.The results suggest the involvement of an additional, critical hydrogen bond in the highest affinity subsite (A), which now appears to require two hydrogen bonds from the 2- and 3-hydroxyls of the galactosyl residue to the protein, and one from the protein to O-4 of that residue.The data obtained with a series of oligosaccharides deoxygenated at position 31, 32,33, 41, 42, or 43 support the binding patterns and subsite-arrangement inferred previously from studies with large numbers of deoxyfluoro-substituted ligands and this family of antibodies.

SYNTHESYS OF O-α-L-FUCOPYRANOSYL-(1->3)-O-β-D-GALACTOPYRANOSYL-(1->4)-2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSE (N-ACETYL-3'-O-α-L-FUCOPYRANOSYLLACTOSAMINE)

Methyl 2-O-benzyl-β-D-galactopyranoside (6) was obtained in five, good yielding steps from methyl β-D-galactopyranoside (1).Treatment of 1 with tert-butylchlorodiphenylsilane in N,N-dimethylformamide in the presence of imidazole afforded a 6-(tert-butyldi

SYNTHESIS OF INTERMEDIATES FOR STEREOSPECIFIC SYNTHESIS OF α- AND β-C-NUCLEOSIDES: RING CONTRACTION OF PROTECTED 2-O-TRIFLUOROMETHANESULPHONATES OF GALACTO- AND ALTRO-PYRANOSIDES

The reactions of sodium azide with methyl 6-O-(tert-butyldiphenyl)silyl-3,4-O-isopropylidene-2-O-trifluoromethanesulphonyl-D-galactopyranosides and with methyl 6-O-(tert-butyldiphenyl)silyl-3,4-O-isopropylidene-2-O-trifluoromethanesulphonyl-α-D-pyranoside

Selective Silylation of β-D-Galactosides. A New Approach to the Synthesis of (1->6)-β-D-Galactopyranooligosaccharides.

A simple and convenient synthesis of β-D-galactopyranose derivatives selectively modified at C-1 and C-6 is described.A key feature is the selective protection of the 6-OH group of methyl-, allyl-,and (p-nitrophenyl)-β-D-galactopyranosides using tert-buty